{"id":"W2021775766","doi":"10.1016/j.jmb.2007.03.058","title":"Mouse 17α-Hydroxysteroid Dehydrogenase (AKR1C21) Binds Steroids Differently from other Aldo-keto Reductases: Identification and Characterization of Amino Acid Residues Critical for Substrate Binding","year":2007,"lang":"en","type":"article","venue":"Journal of Molecular Biology","topic":"Aldose Reductase and Taurine","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université Laval","funders":"","keywords":"Steroid; Dehydrogenase; Hydroxysteroid dehydrogenase; Stereochemistry; Chemistry; Aldo-keto reductase; Oxidoreductase; Binding site; Stereospecificity; Hydroxysteroid Dehydrogenases; Biochemistry; Enzyme; Reductase; Catalysis; Hormone","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005607856,0.0002112852,0.000352839,0.0001858421,0.00006901516,0.00002886859,0.0001929084,0.0002784111,0.000008007535],"category_scores_gemma":[0.0001956566,0.0001874414,0.0001505696,0.00008267556,0.0001924644,0.0000188089,0.00005818189,0.0001336504,0.000001099628],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000195733,"about_ca_system_score_gemma":0.00005415863,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009246926,"about_ca_topic_score_gemma":0.00001276235,"domain_scores_codex":[0.9983265,0.0001626952,0.000784229,0.0003154908,0.0001271952,0.0002838323],"domain_scores_gemma":[0.9987522,0.0000474788,0.0005462396,0.0002649908,0.0002480868,0.0001410498],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004837519,0.0001273911,0.002653711,0.00003899939,0.0002072836,0.00001572001,0.00006206767,8.68902e-7,0.9954938,0.0001328764,0.00001854299,0.0007650388],"study_design_scores_gemma":[0.0009330408,0.0007328807,0.003474867,0.00004120959,0.0001150748,0.00009013372,0.0001024725,0.000009270043,0.9936489,0.0002734927,0.0004023889,0.0001762006],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9644157,0.001187339,0.03353963,0.0001597344,0.0001892398,0.0001853723,0.0003109935,0.000004868527,0.000007079697],"genre_scores_gemma":[0.9975069,0.0002403967,0.001198686,0.00009099643,0.0002945451,0.000006269861,0.000592007,0.00003521817,0.00003501393],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03309112,"threshold_uncertainty_score":0.764364,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01210324477050775,"score_gpt":0.2874124430152352,"score_spread":0.2753091982447274,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}