{"id":"W2021775766","doi":"10.1016/j.jmb.2007.03.058","title":"Mouse 17α-Hydroxysteroid Dehydrogenase (AKR1C21) Binds Steroids Differently from other Aldo-keto Reductases: Identification and Characterization of Amino Acid Residues Critical for Substrate Binding","year":2007,"lang":"en","type":"article","venue":"Journal of Molecular Biology","topic":"Aldose Reductase and Taurine","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université Laval","funders":"","keywords":"Steroid; Dehydrogenase; Hydroxysteroid dehydrogenase; Stereochemistry; Chemistry; Aldo-keto reductase; Oxidoreductase; Binding site; Stereospecificity; Hydroxysteroid Dehydrogenases; Biochemistry; Enzyme; Reductase; Catalysis; Hormone","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002647573,0.0004972258,0.0004464618,0.0002502674,0.0002766547,0.0005370731,0.0005247744,0.0005186974,0.001231971],"category_scores_gemma":[0.0003333588,0.0003301411,0.0005941896,0.0002329734,0.0003025162,0.0003896616,0.0002421818,0.0005940299,0.001074384],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000508368,"about_ca_system_score_gemma":0.0002200853,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008869844,"about_ca_topic_score_gemma":0.0009901366,"domain_scores_codex":[0.9997525,0.00004155934,0.00002694181,0.00006261352,0.00005935222,0.00005704212],"domain_scores_gemma":[0.9995377,0.00008498155,0.0001618415,0.00004344661,0.00005747151,0.0001146837],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001689662,0.00001378137,0.0002576633,0.00001714818,0.000008030863,0.00006498021,0.000009495348,0.00003043154,0.9989642,0.00004729038,0.00001319044,0.0004049157],"study_design_scores_gemma":[0.00002185879,0.0001242961,0.008092517,0.000005634902,0.00003986721,0.000745251,0.00003148873,0.0005418072,0.9884967,0.0000503692,0.001841673,0.000008628263],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994543,0.002399261,0.002131167,0.0001022993,0.00004032182,0.00001506561,0.0002327412,0.00003332114,0.0005027846],"genre_scores_gemma":[0.9923065,0.001544502,0.002635614,0.00009410893,0.00002243257,0.00002179454,0.001097513,0.00004643064,0.002230962],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001231971,"threshold_uncertainty_score":0.004121363,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01210324477050775,"score_gpt":0.2874124430152352,"score_spread":0.2753091982447274,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}