{"id":"W2021809694","doi":"10.2174/187152606776056689","title":"Future Promise of siRNA and Other Nucleic Acid Based Therapeutics for the Treatment of Chronic HCV","year":2006,"lang":"en","type":"review","venue":"Infectious Disorders - Drug Targets","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; Ontario Institute for Cancer Research","funders":"","keywords":"RNA interference; Nucleic acid; Biology; RNA; Ribozyme; Small interfering RNA; Aptamer; Hepatitis C virus; DNA-directed RNA interference; Virology; Small hairpin RNA; Computational biology; Virus; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006299192,0.0006229091,0.0008916019,0.001295888,0.000258581,0.0007681257,0.0006839585,0.00129598,0.003441613],"category_scores_gemma":[0.0003852728,0.0001712589,0.0004015507,0.0008389861,0.0004233073,0.001372918,0.0003422934,0.001290109,0.002209395],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005635147,"about_ca_system_score_gemma":0.000610925,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008338796,"about_ca_topic_score_gemma":0.002141248,"domain_scores_codex":[0.9998614,0.00003180376,0.00001453865,0.00001801159,0.00005759895,0.00001667941],"domain_scores_gemma":[0.9998679,0.00005537915,0.00001346349,0.000004268757,0.00003602649,0.00002301251],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001704965,0.0001810614,0.0001746352,0.00437896,0.00005162907,0.0007067077,0.00008408011,0.00072643,0.007890062,0.006248309,0.02710823,0.9522794],"study_design_scores_gemma":[0.00008473886,0.0003532148,0.0008592539,0.0007802075,0.00004625681,0.002332869,0.00007053697,0.0002813383,0.00155739,0.003465836,0.9901444,0.00002387376],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0006327541,0.9945335,0.0005032013,0.0009499434,0.0004375717,0.0000120725,0.00001398453,0.00001814032,0.002898734],"genre_scores_gemma":[0.00237826,0.9918783,0.0008079847,0.0008320843,0.0004484582,0.00002021825,0.00003112092,0.000003869282,0.003599723],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003441613,"threshold_uncertainty_score":0.01151329,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01454051427314358,"score_gpt":0.2843597077032677,"score_spread":0.2698191934301242,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}