{"id":"W2021835404","doi":"10.1038/cdd.2009.124","title":"Caspase-3-mediated secretion of connective tissue growth factor by apoptotic endothelial cells promotes fibrosis","year":2009,"lang":"en","type":"article","venue":"Cell Death and Differentiation","topic":"Connective Tissue Growth Factor Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":82,"is_retracted":false,"has_abstract":false,"ca_institutions":"Centre Hospitalier Universitaire Sainte-Justine; Centre Hospitalier de l’Université de Montréal; Université de Montréal; Hôpital Notre-Dame","funders":"Canadian Institutes of Health Research; Kidney Foundation of Canada","keywords":"CTGF; Myofibroblast; Growth factor; Cell biology; Fibrosis; Apoptosis; Biology; Connective tissue; Paracrine signalling; Chemistry; Molecular biology; Cancer research; Internal medicine; Medicine; Receptor; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005753973,0.0005997219,0.0004426392,0.0005650513,0.0003402111,0.0007426427,0.0002436572,0.0005641397,0.003041552],"category_scores_gemma":[0.0005166415,0.0002686388,0.0006816309,0.0003074392,0.0003779064,0.0005907586,0.0003241808,0.001981852,0.0008011547],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007414607,"about_ca_system_score_gemma":0.0004501778,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005187354,"about_ca_topic_score_gemma":0.0006975683,"domain_scores_codex":[0.9995265,0.00008838236,0.00005191818,0.00005279016,0.000113577,0.0001668925],"domain_scores_gemma":[0.999548,0.0001102833,0.00009264463,0.00008159153,0.00008121727,0.00008607253],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008337447,0.00009460616,0.0003133223,0.00007650087,0.00001453763,0.0001624018,0.00003589543,0.00008994616,0.9949756,0.0003576196,0.0001740623,0.002871805],"study_design_scores_gemma":[0.0001742379,0.0003259081,0.004365012,0.00001214574,0.00002490569,0.000769,0.0000515686,0.001819756,0.9904853,0.0002741193,0.001689341,0.000008701638],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9815465,0.004188214,0.01011188,0.0005250605,0.0002086102,0.00007113312,0.000405469,0.0002213132,0.002721829],"genre_scores_gemma":[0.9926949,0.001075587,0.003353022,0.0001071711,0.00005093033,0.00004261342,0.0003536306,0.00002195656,0.002300401],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003041552,"threshold_uncertainty_score":0.01017505,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009865026289399703,"score_gpt":0.2410099226554227,"score_spread":0.231144896366023,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}