{"id":"W2021835404","doi":"10.1038/cdd.2009.124","title":"Caspase-3-mediated secretion of connective tissue growth factor by apoptotic endothelial cells promotes fibrosis","year":2009,"lang":"en","type":"article","venue":"Cell Death and Differentiation","topic":"Connective Tissue Growth Factor Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":82,"is_retracted":false,"has_abstract":false,"ca_institutions":"Centre Hospitalier Universitaire Sainte-Justine; Centre Hospitalier de l’Université de Montréal; Université de Montréal; Hôpital Notre-Dame","funders":"Canadian Institutes of Health Research; Kidney Foundation of Canada","keywords":"CTGF; Myofibroblast; Growth factor; Cell biology; Fibrosis; Apoptosis; Biology; Connective tissue; Paracrine signalling; Chemistry; Molecular biology; Cancer research; Internal medicine; Medicine; Receptor; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005615344,0.0001709427,0.000175062,0.00007199253,0.00006775294,0.00002912489,0.00008522764,0.0001493794,0.00006701588],"category_scores_gemma":[0.0001127719,0.0001624675,0.00004755596,0.00007319223,0.00003881574,0.00001081077,0.00003503633,0.00007722189,0.000006904486],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002122188,"about_ca_system_score_gemma":0.00002846527,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005581903,"about_ca_topic_score_gemma":0.000006227021,"domain_scores_codex":[0.9989917,0.00009429285,0.0001848984,0.0003378537,0.0001644212,0.0002268607],"domain_scores_gemma":[0.9994294,0.00005103946,0.000108609,0.0001498742,0.0001446341,0.0001164456],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001074795,0.000118909,0.004352312,0.0000478242,0.00001836159,5.462997e-7,0.0001098949,3.432027e-7,0.9940489,0.00004208169,0.0001430086,0.001010337],"study_design_scores_gemma":[0.0007746764,0.000851655,0.0520478,0.00001051761,0.00002174446,0.000001134723,0.00002728348,0.0001249398,0.9456695,0.0001716038,0.0001406928,0.0001584852],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952194,0.00038309,0.003322338,0.00004594439,0.00005780624,0.0004005864,0.0003462349,0.00001520137,0.0002093805],"genre_scores_gemma":[0.9986113,0.0001618654,0.00008199742,0.00002110961,0.0000648481,0.0000122224,0.0008081837,0.00001459469,0.0002238688],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04837944,"threshold_uncertainty_score":0.6625234,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009865026289399703,"score_gpt":0.2410099226554227,"score_spread":0.231144896366023,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}