{"id":"W2021844025","doi":"10.1186/1471-2407-10-103","title":"Lovastatin induces apoptosis of ovarian cancer cells and synergizes with doxorubicin: potential therapeutic relevance","year":2010,"lang":"en","type":"article","venue":"BMC Cancer","topic":"Cancer, Lipids, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":165,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; Ontario Institute for Cancer Research","funders":"Canadian Institutes of Health Research; University of Pennsylvania","keywords":"Lovastatin; Ovarian cancer; Doxorubicin; Statin; Medicine; Apoptosis; Cancer research; Pharmacology; HMG-CoA reductase; Cisplatin; Cancer cell; Ovarian carcinoma; Cancer; Chemotherapy; Oncology; Internal medicine; Reductase; Biology; Cholesterol; Biochemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000971972,0.0001932618,0.0002424658,0.00004100507,0.00006328866,0.00002291478,0.0001444569,0.0001402482,0.0001201265],"category_scores_gemma":[0.00001161064,0.0001556251,0.00006230902,0.0001037114,0.0002107554,0.000008776025,0.00005058482,0.0001443216,9.754648e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009225158,"about_ca_system_score_gemma":0.0003040539,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001630794,"about_ca_topic_score_gemma":0.004313354,"domain_scores_codex":[0.9989686,0.00003301529,0.000195223,0.000384935,0.0001622614,0.000255963],"domain_scores_gemma":[0.9993235,0.0000150971,0.000154439,0.0003021362,0.0001172457,0.00008750696],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003119119,0.00003075666,0.001697947,0.00006314994,0.00008662653,4.166066e-8,0.0001027714,0.0001857845,0.9814309,0.00009556224,0.002074495,0.01391999],"study_design_scores_gemma":[0.001100239,0.000103257,0.00863192,0.00003841749,0.0001087927,0.00000423458,0.00009100394,0.00002513422,0.8428826,0.00003212076,0.1467292,0.0002531732],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9872902,0.006953391,0.0008429215,0.0001330447,0.004244406,0.0002042179,0.0001144375,0.000010423,0.000206952],"genre_scores_gemma":[0.9871783,0.005120518,0.001424224,0.0002487525,0.004759036,0.0001051553,0.00001101983,0.00003624709,0.001116804],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1446547,"threshold_uncertainty_score":0.6346206,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008178651809952028,"score_gpt":0.245967567772755,"score_spread":0.237788915962803,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}