{"id":"W2021855052","doi":"10.1074/jbc.m110.117382","title":"Enhancing Antibody Fc Heterodimer Formation through Electrostatic Steering Effects","year":2010,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":284,"is_retracted":false,"has_abstract":true,"ca_institutions":"Amgen (Canada)","funders":"","keywords":"Fragment crystallizable region; Biophysics; Chemistry; Recombinant DNA; Antibody; Dimer; Bispecific antibody; Static electricity; Molecule; Protein engineering; Immunoglobulin light chain; Receptor; Biochemistry; Biology; Monoclonal antibody; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003101644,0.0001308424,0.000332812,0.00002375151,0.00006587816,0.00002138357,0.0001211731,0.0001604992,0.0002367838],"category_scores_gemma":[0.0004023857,0.00007775311,0.0001798106,0.00009300958,0.00008785912,0.000118063,0.00004324364,0.0008805066,0.00002051817],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002982572,"about_ca_system_score_gemma":0.00005187998,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003339968,"about_ca_topic_score_gemma":7.890151e-7,"domain_scores_codex":[0.9988846,0.00002672738,0.0004030977,0.0001129931,0.0002897281,0.0002828675],"domain_scores_gemma":[0.9991804,0.0002045536,0.0001928824,0.000104322,0.000160487,0.0001573564],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004000882,0.00008884162,0.002848906,0.0003084275,0.00004447835,0.0001402955,0.00005443969,5.647912e-7,0.9948062,0.0000114043,0.0001165885,0.001179741],"study_design_scores_gemma":[0.0005834836,0.0006169294,0.008839358,0.0001413346,0.00002437867,0.001658726,0.0000295551,0.00004099522,0.9837177,0.0001714514,0.004083895,0.0000922306],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967365,0.0003529179,0.0007529359,0.0005093421,0.000126094,0.00008108081,0.000002426828,0.0000132289,0.001425487],"genre_scores_gemma":[0.9960238,0.0002493995,0.002693573,0.0002134008,0.0005569449,0.000001771705,0.00002064832,0.000007329769,0.0002330707],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01108856,"threshold_uncertainty_score":0.3825412,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02060035569755742,"score_gpt":0.3310087270601716,"score_spread":0.3104083713626142,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}