{"id":"W2021855052","doi":"10.1074/jbc.m110.117382","title":"Enhancing Antibody Fc Heterodimer Formation through Electrostatic Steering Effects","year":2010,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":284,"is_retracted":false,"has_abstract":true,"ca_institutions":"Amgen (Canada)","funders":"","keywords":"Fragment crystallizable region; Biophysics; Chemistry; Recombinant DNA; Antibody; Dimer; Bispecific antibody; Static electricity; Molecule; Protein engineering; Immunoglobulin light chain; Receptor; Biochemistry; Biology; Monoclonal antibody; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002455209,0.0003842657,0.0001463754,0.0001667817,0.0001147715,0.0003241922,0.0002411493,0.0002214039,0.001648142],"category_scores_gemma":[0.000210758,0.0001486898,0.00014962,0.0001618276,0.0001536261,0.0003005186,0.0004923595,0.0003066588,0.0004410715],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001801484,"about_ca_system_score_gemma":0.0001142983,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001638831,"about_ca_topic_score_gemma":0.0003084854,"domain_scores_codex":[0.9998528,0.0000290081,0.0000116069,0.00002892051,0.00004657788,0.00003113064],"domain_scores_gemma":[0.9999045,0.0000198587,0.00002663421,0.000009975236,0.00001839332,0.00002072653],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002932183,0.00002573823,0.0001235099,0.00002933049,0.000004547315,0.00003744861,0.00002200013,0.000249197,0.9955812,0.0006981355,0.0001063752,0.003093233],"study_design_scores_gemma":[0.00001261054,0.00007241539,0.0002664126,0.000002050725,0.000004969019,0.00008187767,0.00001005806,0.002744725,0.9947447,0.00007206706,0.00198309,0.000005012373],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9639634,0.0005410002,0.02876846,0.0001251372,0.00003469165,0.00005909066,0.00008311309,0.0002264537,0.006198622],"genre_scores_gemma":[0.9882876,0.0003296718,0.008515209,0.00008609209,0.000007957392,0.00003847472,0.00008158742,0.000028949,0.002624409],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001648142,"threshold_uncertainty_score":0.005513549,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02060035569755742,"score_gpt":0.3310087270601716,"score_spread":0.3104083713626142,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}