{"id":"W2021855902","doi":"10.1177/095632020501600502","title":"<i>In Vitro</i> Activity of SPD754, a New Deoxycytidine Nucleoside Reverse Transcriptase Inhibitor (NRTI), against 215 HIV-1 Isolates Resistant to Other NRTIs","year":2005,"lang":"en","type":"article","venue":"Antiviral chemistry & chemotherapy","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"Boehringer Ingelheim (Canada)","funders":"","keywords":"Didanosine; Abacavir; Zidovudine; Nucleoside Reverse Transcriptase Inhibitor; Lamivudine; Reverse transcriptase; Virology; Reverse-transcriptase inhibitor; Stavudine; Deoxycytidine; Zalcitabine; Deoxycytidine kinase; Resistance mutation; Biology; Human immunodeficiency virus (HIV); Virus; Viral load; Sida; Chemotherapy; Polymerase chain reaction; Viral disease; Biochemistry; Gemcitabine; Antiretroviral therapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001803603,0.00048315,0.0007740495,0.0001332045,0.00005559494,0.00002268862,0.0001749514,0.0002029819,0.0004196491],"category_scores_gemma":[0.00003301006,0.0004460261,0.0002838671,0.0005634489,0.00008704336,0.0002259678,0.00002886885,0.0002747646,0.0001038955],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002789822,"about_ca_system_score_gemma":0.0002633815,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009020259,"about_ca_topic_score_gemma":0.00002507422,"domain_scores_codex":[0.9978549,0.00002900223,0.0005731165,0.0006287644,0.0003505768,0.0005636668],"domain_scores_gemma":[0.9989265,0.0000416468,0.000164595,0.0005115771,0.0000626148,0.0002930828],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004124481,0.0008839045,0.001530784,0.0001408358,0.0001723285,0.00007556679,0.001004448,0.000001904677,0.9488553,0.000001681879,0.03103713,0.01217158],"study_design_scores_gemma":[0.005503068,0.00007117017,0.0004162193,0.0002841289,0.0000583019,0.0000105944,0.00007228057,0.0000491403,0.8538786,0.000009128259,0.1392908,0.00035654],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9730224,0.0002782221,0.00006552013,0.02150905,0.00004349582,0.0005294655,0.00008725835,0.00008591517,0.00437866],"genre_scores_gemma":[0.9532642,0.0002142133,0.005318855,0.002792809,0.0004067964,0.00002517063,0.00004606514,0.0000938872,0.03783804],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1082537,"threshold_uncertainty_score":0.9997991,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008584953640573333,"score_gpt":0.2439034641049165,"score_spread":0.2353185104643431,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}