{"id":"W2021855902","doi":"10.1177/095632020501600502","title":"<i>In Vitro</i> Activity of SPD754, a New Deoxycytidine Nucleoside Reverse Transcriptase Inhibitor (NRTI), against 215 HIV-1 Isolates Resistant to Other NRTIs","year":2005,"lang":"en","type":"article","venue":"Antiviral chemistry & chemotherapy","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"Boehringer Ingelheim (Canada)","funders":"","keywords":"Didanosine; Abacavir; Zidovudine; Nucleoside Reverse Transcriptase Inhibitor; Lamivudine; Reverse transcriptase; Virology; Reverse-transcriptase inhibitor; Stavudine; Deoxycytidine; Zalcitabine; Deoxycytidine kinase; Resistance mutation; Biology; Human immunodeficiency virus (HIV); Virus; Viral load; Sida; Chemotherapy; Polymerase chain reaction; Viral disease; Biochemistry; Gemcitabine; Antiretroviral therapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000199557,0.0003951438,0.0003172622,0.0003178798,0.000153797,0.0003173868,0.0002138502,0.0002046645,0.0005895085],"category_scores_gemma":[0.0003428709,0.0001231605,0.0003264271,0.0004234645,0.0001825028,0.0001303419,0.0001625878,0.0002354755,0.0001975475],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002280913,"about_ca_system_score_gemma":0.0001995848,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003292429,"about_ca_topic_score_gemma":0.003405008,"domain_scores_codex":[0.9996406,0.00008312354,0.00004911511,0.00006723517,0.000102968,0.00005693639],"domain_scores_gemma":[0.9997801,0.00006086318,0.00004474287,0.00002904435,0.00004951564,0.00003580054],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006054555,0.0001700826,0.007422679,0.00009667721,0.0000398643,0.0001017203,0.00006722204,0.000694692,0.9845943,0.00004329143,0.0001318918,0.006032084],"study_design_scores_gemma":[0.00003698474,0.005543978,0.05572896,0.00001345585,0.0001024782,0.0007760598,0.00008618422,0.001356557,0.9338043,0.00002810334,0.002507122,0.0000158254],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974739,0.0006247992,0.0003035279,0.0000178254,0.000008221078,0.00002947309,0.0008442262,0.00001186582,0.0006861973],"genre_scores_gemma":[0.993575,0.0006329716,0.00206293,0.00003757586,0.00001760302,0.00003225259,0.002938516,0.000007523569,0.0006956448],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003292429,"threshold_uncertainty_score":0.006546557,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008584953640573333,"score_gpt":0.2439034641049165,"score_spread":0.2353185104643431,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}