{"id":"W2021857073","doi":"10.1371/journal.pone.0062349","title":"Treatment of Colorectal Cancer Using a Combination of Liposomal Irinotecan (Irinophore C™) and 5-Fluorouracil","year":2013,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; Centre for Drug Research and Development; BC Cancer Agency; University of Alberta","funders":"Canadian Institutes of Health Research; Terry Fox Research Institute; Pfizer","keywords":"Irinotecan; Pharmacokinetics; Fluorouracil; Biodistribution; Pharmacology; In vivo; Colorectal cancer; Medicine; Cytotoxicity; Combination therapy; Toxicity; Cancer; Chemistry; In vitro; Internal medicine; Biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00001453827,0.00007417161,0.0001399959,0.00002186415,0.00001942525,0.000004859546,0.00003446225,0.00005804517,0.0000267481],"category_scores_gemma":[0.000002835656,0.00006878783,0.00002945452,0.00003249455,0.00004025866,0.00000242374,0.00002294871,0.00001499113,3.77125e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002386562,"about_ca_system_score_gemma":0.00004306917,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006443632,"about_ca_topic_score_gemma":0.00005967808,"domain_scores_codex":[0.999581,0.0000118849,0.0001141924,0.0001209711,0.00008295371,0.00008896065],"domain_scores_gemma":[0.9996875,0.000003683857,0.00007787878,0.00009037814,0.0001075606,0.00003298731],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005644617,0.0006906185,0.00286652,0.00003254695,0.0001870684,1.917169e-7,0.0001261889,0.00000390042,0.9871106,0.00006038271,0.000001299919,0.008864293],"study_design_scores_gemma":[0.0007162844,0.00159839,0.003451537,0.00002497826,0.00008554743,0.000001433837,0.00003297387,0.0009392021,0.9929787,0.00005924302,0.00004215092,0.00006956368],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9984054,0.001151244,0.00003068903,0.00005313994,0.00002045293,0.0002341136,0.00002128522,0.000002605286,0.00008106247],"genre_scores_gemma":[0.9976056,0.001002228,0.001190493,0.0000126379,0.00003238241,0.00003888122,0.00001343634,0.00001003172,0.00009426765],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00879473,"threshold_uncertainty_score":0.2805086,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03738456449086898,"score_gpt":0.2491077233494121,"score_spread":0.2117231588585431,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}