{"id":"W2021861409","doi":"10.1586/egh.09.25","title":"How to manage difficult Crohn’s disease: optimum delivery of anti-TNFs","year":2009,"lang":"en","type":"review","venue":"Expert Review of Gastroenterology & Hepatology","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Medicine; Natalizumab; Crohn's disease; Adverse effect; Disease; Inflammatory bowel disease; Drug; Intensive care medicine; Internal medicine; Immunology; Pharmacology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005517004,0.0007259533,0.001913056,0.001283279,0.0002739747,0.001060277,0.0008328771,0.001733253,0.003438478],"category_scores_gemma":[0.0007241181,0.0002153384,0.0005142356,0.0007919408,0.000474,0.001607706,0.0005644218,0.002488592,0.004305201],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004385429,"about_ca_system_score_gemma":0.0006609928,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007772857,"about_ca_topic_score_gemma":0.001199467,"domain_scores_codex":[0.9997602,0.00005491472,0.00003080968,0.00002919847,0.0001016651,0.00002312961],"domain_scores_gemma":[0.9998189,0.00006760313,0.00003447125,0.000006694044,0.0000462578,0.00002617093],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00007876642,0.00009985746,0.0001923194,0.009228883,0.00009577242,0.0005390915,0.00006039565,0.0002656861,0.002213666,0.002648,0.05241941,0.9321581],"study_design_scores_gemma":[0.0001132508,0.0001519374,0.001437804,0.007743493,0.0001123621,0.006012799,0.0001592116,0.0001691329,0.0006853234,0.005784959,0.9775946,0.00003514872],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002297976,0.9939206,0.0007150339,0.002727347,0.000655964,0.00001603877,0.00001961765,0.00002483642,0.001690924],"genre_scores_gemma":[0.001228662,0.9946184,0.001443043,0.001025977,0.0006941459,0.00002066518,0.00003710829,0.00000501275,0.0009271564],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003438478,"threshold_uncertainty_score":0.01150286,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0124218196749254,"score_gpt":0.2885175302940834,"score_spread":0.276095710619158,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}