{"id":"W2021871876","doi":"10.1097/01.jcp.0000088903.24613.2a","title":"Dose-Related Pharmacokinetics and Pharmacodynamics of Valproate in the Elderly","year":2003,"lang":"en","type":"article","venue":"Journal of Clinical Psychopharmacology","topic":"Pharmacological Effects and Toxicity Studies","field":"Medicine","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sunnybrook Health Science Centre","funders":"Abbott Laboratories","keywords":"Pharmacokinetics; Free fraction; Pharmacology; Pharmacodynamics; Medicine; Valproic Acid; Serum concentration; Therapeutic index; Drug; Drug interaction; Population; Anticonvulsant; Volume of distribution; Internal medicine; Epilepsy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004013572,0.0002374512,0.0004316848,0.0001582905,0.00008453724,0.0001728548,0.00008532071,0.0002359268,0.0004350255],"category_scores_gemma":[0.001214921,0.0001585417,0.0002083149,0.000141931,0.0001954057,0.0001743555,0.0001068954,0.0002558839,0.000136729],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000150028,"about_ca_system_score_gemma":0.0001215213,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003292949,"about_ca_topic_score_gemma":0.0005308064,"domain_scores_codex":[0.9997922,0.00008208651,0.00001844181,0.00002825761,0.00006438161,0.00001469639],"domain_scores_gemma":[0.9995895,0.0001211181,0.0001305361,0.00005157422,0.00005413655,0.00005324355],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.05715501,0.002129824,0.1528436,0.0003587086,0.0006499304,0.0006468088,0.0004903297,0.003867467,0.6854051,0.0001238082,0.0003305574,0.09599894],"study_design_scores_gemma":[0.0009330022,0.06796965,0.8372497,0.00001494083,0.0003124391,0.001239761,0.0001019754,0.002774195,0.08774466,0.0001617031,0.001465987,0.00003205487],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9986082,0.0007022802,0.0003680339,0.00000766733,0.000003803648,0.00002786666,0.00006111894,0.00001161633,0.0002095504],"genre_scores_gemma":[0.9986865,0.0003372473,0.0004771928,0.0000396211,0.00001068633,0.00003820603,0.0001245481,0.000004872969,0.0002811933],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0004350255,"threshold_uncertainty_score":0.002122641,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06423391777545003,"score_gpt":0.4660996973029486,"score_spread":0.4018657795274986,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}