{"id":"W2021901688","doi":"10.1038/cr.2009.55","title":"The adenoviral E1A protein displaces corepressors and relieves gene repression by unliganded thyroid hormone receptors in vivo","year":2009,"lang":"en","type":"article","venue":"Cell Research","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":false,"ca_institutions":"Mount Sinai Hospital; Western University","funders":"National Institutes of Health","keywords":"Corepressor; Biology; Psychological repression; Coactivator; Thyroid hormone receptor; Nuclear receptor; Repressor; Cell biology; Receptor; Regulation of gene expression; Molecular biology; Gene; Gene expression; Transcription factor; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004122474,0.0004878792,0.0003835674,0.0005948949,0.000353617,0.0007656253,0.0006859109,0.000402136,0.002092993],"category_scores_gemma":[0.0002668386,0.0003493845,0.0003946006,0.0002591177,0.0007430034,0.0003597965,0.0004469843,0.001096587,0.0007267656],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007387435,"about_ca_system_score_gemma":0.0005952414,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002932703,"about_ca_topic_score_gemma":0.002953632,"domain_scores_codex":[0.9996394,0.00004863719,0.00003566119,0.00006709378,0.0001015562,0.0001076539],"domain_scores_gemma":[0.9996258,0.0001408855,0.00005637429,0.00006263192,0.0000208218,0.0000934752],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001242328,0.00003560819,0.0001076121,0.00001479481,0.000005895926,0.00002972278,0.00001568322,0.00007907848,0.998354,0.0004333085,0.00004698915,0.0007530298],"study_design_scores_gemma":[0.00001710587,0.00006888973,0.0006316817,0.000002164137,0.00000615563,0.0001085089,0.00001946104,0.0006606106,0.9969194,0.00006273457,0.001498975,0.000004334791],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9907041,0.001744329,0.004419153,0.0002207724,0.00009423443,0.00002263296,0.0003873807,0.0002718613,0.002135557],"genre_scores_gemma":[0.9924741,0.000429138,0.002256985,0.00006626609,0.0000213689,0.00001366297,0.0006497357,0.00009899179,0.003989721],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002932703,"threshold_uncertainty_score":0.007001758,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01791384115478156,"score_gpt":0.3194879477392357,"score_spread":0.3015741065844541,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}