{"id":"W2021918026","doi":"10.1016/s0140-6736(00)03137-8","title":"Idiosyncratic drug reactions: the reactive metabolite syndromes","year":2000,"lang":"en","type":"review","venue":"The Lancet","topic":"Drug-Induced Adverse Reactions","field":"Medicine","cited_by":329,"is_retracted":false,"has_abstract":false,"ca_institutions":"Health Sciences Centre; University of Toronto; Sunnybrook Health Science Centre","funders":"","keywords":"Drug reaction; Medicine; Intensive care medicine; Epidemiology; Drug; Identification (biology); Metabolite; Pharmacology; Pathology; Internal medicine; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007173633,0.00157312,0.002831978,0.002981413,0.0002394587,0.001384762,0.00115041,0.0016866,0.003101734],"category_scores_gemma":[0.001200084,0.0002783577,0.0006568788,0.003494135,0.0006701043,0.001629031,0.0007873815,0.002122293,0.002343504],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005943193,"about_ca_system_score_gemma":0.0008500419,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001034744,"about_ca_topic_score_gemma":0.002433087,"domain_scores_codex":[0.9996274,0.00008390247,0.00005114836,0.00004903573,0.0001586018,0.0000300123],"domain_scores_gemma":[0.9989775,0.0004601608,0.0002579505,0.0000282306,0.0001927964,0.00008339845],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00009367419,0.00005791135,0.0002575575,0.01094926,0.0001159083,0.0005229352,0.0000355791,0.0003647091,0.0009041865,0.001654801,0.04882295,0.9362205],"study_design_scores_gemma":[0.00009540826,0.0001233996,0.001497961,0.005186451,0.0002386828,0.005393845,0.00009537087,0.0001890249,0.0003101637,0.002700426,0.9841357,0.00003352628],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00006002247,0.9983793,0.0001728734,0.0002217491,0.0003342862,0.000004024945,0.00001093015,0.000009649782,0.0008070811],"genre_scores_gemma":[0.0006781312,0.9973567,0.0002228337,0.0004868236,0.0006291734,0.00000585375,0.00002435443,0.000001867055,0.0005943893],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003101734,"threshold_uncertainty_score":0.01037633,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1001053210266022,"score_gpt":0.3716324322497108,"score_spread":0.2715271112231086,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}