{"id":"W2021923583","doi":"10.1074/jbc.m009170200","title":"Two Classes of Androgen Receptor Elements Mediate Cooperativity through Allosteric Interactions","year":2001,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":71,"is_retracted":false,"has_abstract":true,"ca_institutions":"Vancouver General Hospital","funders":"","keywords":"Allosteric regulation; Cooperativity; Androgen receptor; Chemistry; Cooperative binding; Receptor; Biophysics; Cell biology; Biology; Biochemistry; Genetics; Binding site; Prostate cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002432848,0.0003105708,0.0003441292,0.0002015173,0.0002560682,0.0004553059,0.0004419248,0.0003163295,0.00156674],"category_scores_gemma":[0.000553142,0.0002254548,0.0003065659,0.00009194977,0.0004537479,0.0002541741,0.0002899435,0.0005495619,0.0004581733],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002519921,"about_ca_system_score_gemma":0.000195629,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002416877,"about_ca_topic_score_gemma":0.0008961278,"domain_scores_codex":[0.9995996,0.00005445763,0.00002151998,0.00009059655,0.000145355,0.00008842861],"domain_scores_gemma":[0.9996934,0.00009065535,0.000062545,0.00005033211,0.00003586352,0.00006725963],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001498931,0.00008827675,0.001559398,0.00004082512,0.0000104933,0.0001188187,0.00007427851,0.0001794629,0.989953,0.002144395,0.00007360192,0.005607614],"study_design_scores_gemma":[0.0001120227,0.0008786208,0.02273135,0.00001668163,0.00004911847,0.001529371,0.0001203823,0.00647614,0.9599706,0.00207726,0.00599534,0.00004316523],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9732245,0.001240773,0.01931918,0.0002165647,0.00007895749,0.0000837778,0.00009727333,0.0002838627,0.005455182],"genre_scores_gemma":[0.9931008,0.0002208806,0.004947038,0.00006675455,0.00002170057,0.00003645234,0.0000844797,0.00001315968,0.001508694],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00156674,"threshold_uncertainty_score":0.005241275,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02196067833193337,"score_gpt":0.3015829039407225,"score_spread":0.2796222256087891,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}