{"id":"W2021943338","doi":"10.2165/00003088-200342060-00004","title":"Pharmacokinetics of Rofecoxib","year":2003,"lang":"en","type":"review","venue":"Clinical Pharmacokinetics","topic":"Inflammatory mediators and NSAID effects","field":"Medicine","cited_by":27,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"","keywords":"Rofecoxib; Pharmacology; Pharmacokinetics; Medicine; Volume of distribution; Drug interaction; Enterohepatic circulation; Bioavailability; Internal medicine; Chemistry; Cyclooxygenase; Metabolism; Enzyme; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006027705,0.000875577,0.002157561,0.001558137,0.0001399499,0.0007981742,0.0005582976,0.0006586447,0.002900636],"category_scores_gemma":[0.001040547,0.000320738,0.0006020775,0.001594868,0.0002797846,0.0008742503,0.0002615145,0.001007176,0.001339629],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005779752,"about_ca_system_score_gemma":0.0009277801,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001267419,"about_ca_topic_score_gemma":0.00242385,"domain_scores_codex":[0.9997935,0.00004222399,0.00004516351,0.0000312888,0.00007429188,0.00001364498],"domain_scores_gemma":[0.9995773,0.0001608614,0.0001487591,0.00001328109,0.00008069964,0.00001918672],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0006869258,0.0001299793,0.0003838989,0.01298822,0.0002502582,0.0003852342,0.00004172088,0.0005847451,0.004421136,0.0005552723,0.01388959,0.965683],"study_design_scores_gemma":[0.0005002515,0.001462264,0.005410758,0.003916749,0.001615184,0.006698566,0.00008215563,0.0005926357,0.005831935,0.0007616636,0.973069,0.0000588867],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0008013854,0.9977348,0.0002318102,0.0001979913,0.00008490742,0.000008633104,0.00004562102,0.00001366162,0.0008810302],"genre_scores_gemma":[0.003838904,0.9943578,0.0003153324,0.0001799224,0.0001315415,0.0000114511,0.00007150364,0.00000289577,0.001090703],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002900636,"threshold_uncertainty_score":0.009703577,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1632276544545575,"score_gpt":0.5030552790391593,"score_spread":0.3398276245846018,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}