{"id":"W2021961666","doi":"10.1021/tx300341r","title":"Direct Oxidation and Covalent Binding of Isoniazid to Rodent Liver and Human Hepatic Microsomes: Humans Are More Like Mice than Rats","year":2012,"lang":"en","type":"article","venue":"Chemical Research in Toxicology","topic":"Drug-Induced Hepatotoxicity and Protection","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":106,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"Metabolite; Liver injury; Chemistry; Microsome; Toxicity; Alanine transaminase; Sorbitol dehydrogenase; Pharmacology; Biochemistry; Endocrinology; Enzyme; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00259696,0.0002235445,0.000431993,0.0004873224,0.0003134526,0.00002584431,0.0002468366,0.0006218104,0.0001482375],"category_scores_gemma":[0.0004092352,0.0002289143,0.0000507938,0.0004731421,0.000602758,0.0001822289,0.0003980631,0.001297347,0.00004202337],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003151984,"about_ca_system_score_gemma":0.00004915299,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001707251,"about_ca_topic_score_gemma":0.0001797141,"domain_scores_codex":[0.9969167,0.0009902512,0.000433975,0.0004723424,0.0002773381,0.0009094704],"domain_scores_gemma":[0.9981376,0.0009328515,0.0001300808,0.0001991546,0.0001288229,0.0004715171],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002316354,0.0005433338,0.07392754,0.0003103268,0.00004340481,0.00001551532,0.00233039,0.000004876788,0.920136,0.0002073041,0.0004036684,0.001845961],"study_design_scores_gemma":[0.0008594475,0.0002512179,0.03899535,0.0001055325,0.00002948568,0.00002509447,0.0004402219,0.0001220794,0.9539666,0.0001128345,0.004864981,0.0002272096],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962562,0.0008023117,0.00001007655,0.001066837,0.0002704299,0.0009988575,0.00003426217,0.00003332435,0.0005277278],"genre_scores_gemma":[0.9984472,0.0004276272,0.000135989,0.0003778327,0.0001751017,0.000196982,0.00002004095,0.00002664737,0.0001925596],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0349322,"threshold_uncertainty_score":0.9334856,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2611317205175978,"score_gpt":0.4980901951220797,"score_spread":0.236958474604482,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}