{"id":"W2021961666","doi":"10.1021/tx300341r","title":"Direct Oxidation and Covalent Binding of Isoniazid to Rodent Liver and Human Hepatic Microsomes: Humans Are More Like Mice than Rats","year":2012,"lang":"en","type":"article","venue":"Chemical Research in Toxicology","topic":"Drug-Induced Hepatotoxicity and Protection","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":106,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"Metabolite; Liver injury; Chemistry; Microsome; Toxicity; Alanine transaminase; Sorbitol dehydrogenase; Pharmacology; Biochemistry; Endocrinology; Enzyme; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005074805,0.0006939671,0.0002145755,0.0003211125,0.000148196,0.0002614118,0.0001944748,0.0003902681,0.001662092],"category_scores_gemma":[0.0002127553,0.0003039939,0.0003435054,0.0001890444,0.000323471,0.0003081726,0.0002168571,0.0006377435,0.0006055462],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000146771,"about_ca_system_score_gemma":0.0001534806,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004319147,"about_ca_topic_score_gemma":0.0007350802,"domain_scores_codex":[0.9995766,0.0001554769,0.00002891285,0.0001192206,0.00006677081,0.0000529311],"domain_scores_gemma":[0.999835,0.00001998909,0.00005745112,0.00004462481,0.00002499944,0.00001791515],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006284946,0.0001235691,0.002535742,0.0001486933,0.00005873662,0.0001540842,0.00006959213,0.00003119767,0.989053,0.000215117,0.000196908,0.006784895],"study_design_scores_gemma":[0.00007046596,0.00380039,0.02682707,0.00002715081,0.0001053792,0.001901501,0.0001125463,0.0003122624,0.9556458,0.0002178135,0.01096327,0.00001624485],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9516326,0.01155729,0.02946592,0.0006546549,0.0002259723,0.0002156341,0.0005909437,0.0003016951,0.005355338],"genre_scores_gemma":[0.9839408,0.003240724,0.007281856,0.0003136825,0.00004123056,0.0001009444,0.001098909,0.00003382038,0.003948012],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001662092,"threshold_uncertainty_score":0.005560279,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2611317205175978,"score_gpt":0.4980901951220797,"score_spread":0.236958474604482,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}