{"id":"W2021979804","doi":"10.1016/j.pep.2003.09.003","title":"Expression and purification of the recombinant diphtheria fusion toxin DT388IL3 for phase I clinical trials","year":2003,"lang":"en","type":"article","venue":"Protein Expression and Purification","topic":"Toxin Mechanisms and Immunotoxins","field":"Immunology and Microbiology","cited_by":47,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia; BC Cancer Agency","funders":"National Center for Research Resources; National Cancer Institute; National Institutes of Health","keywords":"Diphtheria toxin; Recombinant DNA; Fusion protein; Diphtheria; Toxin; Virology; Fusion; Chemistry; Microbiology; Medicine; Biology; Vaccination; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007867306,0.000503945,0.0005179486,0.0003668773,0.0003549434,0.0005503243,0.0003234494,0.0005377657,0.00210522],"category_scores_gemma":[0.0004332454,0.0002892872,0.0004933188,0.0005356108,0.0002437975,0.0001751136,0.0002986957,0.001217289,0.001715628],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000953014,"about_ca_system_score_gemma":0.0008536648,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001126132,"about_ca_topic_score_gemma":0.001101066,"domain_scores_codex":[0.9996309,0.00006494902,0.00002214602,0.00003585,0.0001202783,0.0001258688],"domain_scores_gemma":[0.9998677,0.0000198402,0.00002344317,0.00002083311,0.00003672383,0.00003149822],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006416768,0.000216152,0.0004332479,0.0001180346,0.00001877968,0.00008496467,0.00005416312,0.0004476175,0.9832569,0.0004470401,0.001934304,0.0123472],"study_design_scores_gemma":[0.0006774825,0.002303007,0.004351204,0.00004393758,0.00009202701,0.0007173885,0.00005010145,0.002097037,0.9428408,0.0003912825,0.0464197,0.00001601862],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8969625,0.007796393,0.07190007,0.002324544,0.0003477106,0.003870305,0.008398464,0.0006924861,0.007707539],"genre_scores_gemma":[0.9147756,0.004145032,0.04596134,0.000643992,0.00007749211,0.001421405,0.01932682,0.0001588498,0.0134894],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00210522,"threshold_uncertainty_score":0.007042587,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0704161332446749,"score_gpt":0.3544415884491152,"score_spread":0.2840254552044403,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}