{"id":"W2021985005","doi":"10.1182/blood-2007-05-088286","title":"Perforin-dependent apoptosis functionally compensates Fas deficiency in activation-induced cell death of human T lymphocytes","year":2007,"lang":"en","type":"article","venue":"Blood","topic":"Cell death mechanisms and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier Universitaire Sainte-Justine","funders":"Ligue Contre le Cancer; Sixth Framework Programme; Institut National de la Santé et de la Recherche Médicale; Agence Nationale de la Recherche","keywords":"Cytotoxic T cell; Perforin; Fas receptor; Granzyme; Biology; Apoptosis; Programmed cell death; Immunology; Fas ligand; T cell; T-cell receptor; Peripheral tolerance; Antigen; Cell biology; Molecular biology; Immune system; CD8; In vitro; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000163011,0.0002565772,0.0002136034,0.0002378402,0.00008379068,0.0003080528,0.0001104651,0.0002278547,0.0008595663],"category_scores_gemma":[0.0003125384,0.00009363485,0.0001296662,0.0001626618,0.0001869066,0.0001472038,0.000212576,0.0002863502,0.000303896],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001687766,"about_ca_system_score_gemma":0.0001204174,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001335088,"about_ca_topic_score_gemma":0.00009213278,"domain_scores_codex":[0.9998467,0.00003646766,0.00002147027,0.00003146307,0.0000291068,0.00003482534],"domain_scores_gemma":[0.9998279,0.00003679164,0.00004704098,0.00004033321,0.00001403375,0.00003387226],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004237908,0.00002729049,0.00159224,0.00003165928,0.00000894509,0.0004637666,0.00001988249,0.0001101861,0.9937172,0.0001045308,0.00003017109,0.003470238],"study_design_scores_gemma":[0.0002122166,0.001190337,0.02684809,0.00001071703,0.00006733256,0.01108263,0.00005166098,0.002223212,0.9549221,0.0002691628,0.003113704,0.000008941659],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9985164,0.0005572602,0.0005958407,0.00001636823,0.000003950364,0.000005105583,0.00005237649,0.00003812128,0.0002145714],"genre_scores_gemma":[0.9991046,0.000153576,0.0003469166,0.000007523945,0.00000426936,0.000005883099,0.0001246951,0.000005090135,0.0002473284],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008595663,"threshold_uncertainty_score":0.002875507,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01370624859744847,"score_gpt":0.2383174784024941,"score_spread":0.2246112298050456,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}