{"id":"W2021997289","doi":"10.1038/clpt.2011.245","title":"Pathways to Drug Development for Autism Spectrum Disorders","year":2011,"lang":"en","type":"review","venue":"Clinical Pharmacology & Therapeutics","topic":"Genetics and Neurodevelopmental Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":57,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"Rett syndrome; Autism; Psychiatry; Medicine; Clinical trial; Neuropathology; Fragile X syndrome; Pharmacotherapy; Autism spectrum disorder; Drug development; Neurochemical; Psychology; Drug; Neuroscience; Disease; Pathology; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005133963,0.0007159706,0.001224825,0.0001211521,0.0001988946,0.00002211944,0.000915117,0.0006870423,0.00007426857],"category_scores_gemma":[0.00001253945,0.0006571185,0.0007846815,0.0001609357,0.0002079455,0.000002220336,0.000489626,0.0004634824,0.0001809585],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004354221,"about_ca_system_score_gemma":0.0008541097,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001011608,"about_ca_topic_score_gemma":0.00002620426,"domain_scores_codex":[0.9963588,0.0003058211,0.001277312,0.001180728,0.0001200829,0.0007572536],"domain_scores_gemma":[0.9986521,0.0001458941,0.0003724011,0.0004692148,0.00002997585,0.0003303855],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001560762,0.0007711444,0.0000268274,0.001167042,0.002028636,0.000002985751,0.0001374711,0.000002362368,0.0002616107,0.00006025338,0.02843134,0.9669542],"study_design_scores_gemma":[0.0007849411,0.0005047433,0.0001304572,0.0001580459,0.001034182,0.000004780023,0.000007700109,0.000001865587,0.0003127569,0.0001996233,0.9960837,0.0007771757],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0008705414,0.9902778,0.0009150649,0.0009171321,0.003902993,0.002706811,0.00009895213,0.00004499626,0.0002656899],"genre_scores_gemma":[0.0001939511,0.9816349,0.002588162,0.01315396,0.0002439261,0.0006781195,0.0003953748,0.0001840481,0.0009275424],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9676524,"threshold_uncertainty_score":0.999588,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1234715519760863,"score_gpt":0.408684906927953,"score_spread":0.2852133549518667,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}