{"id":"W2021997289","doi":"10.1038/clpt.2011.245","title":"Pathways to Drug Development for Autism Spectrum Disorders","year":2011,"lang":"en","type":"review","venue":"Clinical Pharmacology & Therapeutics","topic":"Genetics and Neurodevelopmental Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":57,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"Rett syndrome; Autism; Psychiatry; Medicine; Clinical trial; Neuropathology; Fragile X syndrome; Pharmacotherapy; Autism spectrum disorder; Drug development; Neurochemical; Psychology; Drug; Neuroscience; Disease; Pathology; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004179944,0.0008051198,0.001003077,0.001908904,0.0003734628,0.0009878475,0.0007285022,0.001065989,0.008075422],"category_scores_gemma":[0.0004876628,0.0002391994,0.000455781,0.001315344,0.0004741227,0.001094619,0.0007842492,0.00194282,0.005363072],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007383529,"about_ca_system_score_gemma":0.0008721582,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008920879,"about_ca_topic_score_gemma":0.002663688,"domain_scores_codex":[0.9998528,0.00003307462,0.00001563096,0.00002488811,0.00005792533,0.00001573918],"domain_scores_gemma":[0.9998259,0.000070305,0.00002716957,0.000007929456,0.00004596556,0.00002272929],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00008340272,0.0001748999,0.0001880013,0.00677782,0.00007743858,0.0005773297,0.00006365703,0.000524671,0.003592672,0.01051471,0.04670414,0.9307212],"study_design_scores_gemma":[0.0000402123,0.0001164993,0.0005114644,0.001322505,0.00004265845,0.001419528,0.00003384381,0.0001024783,0.0006962532,0.003781959,0.9919183,0.0000143946],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0003657982,0.9914857,0.0004858743,0.0008810809,0.0002541635,0.00002003749,0.00006482513,0.00003573874,0.006406742],"genre_scores_gemma":[0.001540796,0.9941483,0.0006059775,0.0004458074,0.0001102895,0.00002351854,0.00006248447,0.000003968545,0.003059041],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.008075422,"threshold_uncertainty_score":0.02701497,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1234715519760863,"score_gpt":0.408684906927953,"score_spread":0.2852133549518667,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}