{"id":"W2022002630","doi":"10.1021/bi034480t","title":"Energetics and Specificity of Interactions within Ub·Uev·Ubc13 Human Ubiquitin Conjugation Complexes","year":2003,"lang":"en","type":"article","venue":"Biochemistry","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":42,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan; University of Alberta","funders":"","keywords":"Isothermal titration calorimetry; Chemistry; Kinetics; Dissociation (chemistry); Ubiquitin; Titration; Dissociation constant; Energetics; Biochemistry; Acceptor; Protein–protein interaction; Stereochemistry; Biophysics; Organic chemistry; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004030802,0.0004244359,0.000420662,0.0002928597,0.0005437331,0.0007064342,0.0005161107,0.0003533687,0.00168981],"category_scores_gemma":[0.0007565482,0.0003604174,0.0002791268,0.0002036971,0.0006409514,0.0004620824,0.0002750535,0.0005162706,0.0004297733],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009257111,"about_ca_system_score_gemma":0.0002654122,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00191223,"about_ca_topic_score_gemma":0.001758255,"domain_scores_codex":[0.9995567,0.00007438863,0.00001524254,0.0001185462,0.0001319958,0.0001030224],"domain_scores_gemma":[0.9997073,0.0001393031,0.00004835641,0.00001043501,0.00003344052,0.00006108925],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006025287,0.0001221586,0.006249976,0.0001187784,0.00008929506,0.0001702956,0.0002886474,0.01033396,0.9759077,0.001183967,0.0002527344,0.004679971],"study_design_scores_gemma":[0.00003747843,0.0003373091,0.02453089,0.00001349715,0.00005162404,0.0002352795,0.0002177983,0.08989787,0.8829842,0.0005154707,0.001108941,0.00006964458],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978563,0.0002469204,0.001207903,0.00002746964,0.000004665535,0.000005304223,0.00004354703,0.00002647684,0.0005813983],"genre_scores_gemma":[0.9990258,0.0001057835,0.0002988992,0.00001248825,0.000002205664,0.00000806707,0.0001194442,0.0000145806,0.000412639],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00191223,"threshold_uncertainty_score":0.00671649,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02083559068460038,"score_gpt":0.2673780514967628,"score_spread":0.2465424608121624,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}