{"id":"W2022002630","doi":"10.1021/bi034480t","title":"Energetics and Specificity of Interactions within Ub·Uev·Ubc13 Human Ubiquitin Conjugation Complexes","year":2003,"lang":"en","type":"article","venue":"Biochemistry","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":42,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan; University of Alberta","funders":"","keywords":"Isothermal titration calorimetry; Chemistry; Kinetics; Dissociation (chemistry); Ubiquitin; Titration; Dissociation constant; Energetics; Biochemistry; Acceptor; Protein–protein interaction; Stereochemistry; Biophysics; Organic chemistry; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001635318,0.0001553791,0.0001493283,0.0000236948,0.0001018755,0.00002055446,0.0001044459,0.000135678,0.00009702065],"category_scores_gemma":[0.0001242515,0.0001651228,0.00006048757,0.00005897363,0.0001798328,0.000003541484,0.00005663945,0.0001011616,0.000002784324],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001296506,"about_ca_system_score_gemma":0.00005236133,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001284483,"about_ca_topic_score_gemma":0.000009282527,"domain_scores_codex":[0.9991148,0.00004769877,0.0002807691,0.0002953575,0.000103634,0.0001577627],"domain_scores_gemma":[0.9993448,0.00001472518,0.0001645116,0.0002863143,0.0001038821,0.00008571758],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001886734,0.00006598283,0.00117864,0.00006902956,0.00002515073,8.838473e-7,0.00007318328,0.000005422356,0.9963232,0.001622707,0.0005084593,0.0001085062],"study_design_scores_gemma":[0.000309819,0.00008179667,0.0002704713,0.00002947246,0.00001471847,0.00002814603,0.0002318665,0.0000134114,0.9881645,0.0002581809,0.01041816,0.0001794685],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9891909,0.0004702447,0.0003026382,0.00004096154,0.00008722889,0.00009947873,0.00006285572,0.00001425546,0.009731436],"genre_scores_gemma":[0.9969553,0.00004592958,0.001442952,0.00007016762,0.0001376607,0.00001336978,0.000199069,0.00001748035,0.001118066],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009909705,"threshold_uncertainty_score":0.6733512,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02083559068460038,"score_gpt":0.2673780514967628,"score_spread":0.2465424608121624,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}