{"id":"W2022012719","doi":"10.1021/ja028962o","title":"Structure-Switching Signaling Aptamers","year":2003,"lang":"en","type":"article","venue":"Journal of the American Chemical Society","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1025,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"","keywords":"Aptamer; Chemistry; Oligonucleotide; DNA; Duplex (building); Nucleic acid; Fluorophore; Biophysics; A-DNA; Fluorescence; Quenching (fluorescence); Combinatorial chemistry; Biochemistry; Molecular biology; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000317026,0.000430703,0.0002772876,0.0002045514,0.0001426421,0.0004813358,0.0003225862,0.0003452152,0.0009384316],"category_scores_gemma":[0.000392972,0.0002039591,0.0002605101,0.0001660141,0.0002671731,0.0003638026,0.000230744,0.0007393637,0.0006313872],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003836052,"about_ca_system_score_gemma":0.0001708356,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001023889,"about_ca_topic_score_gemma":0.0001480386,"domain_scores_codex":[0.9997159,0.00004442358,0.00002136913,0.00007718709,0.00008950341,0.00005168582],"domain_scores_gemma":[0.9998627,0.00003085301,0.00002920313,0.00001825028,0.00002670294,0.00003233472],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003855727,0.00001285454,0.00007472625,0.00002536826,0.000002482087,0.00002873567,0.00002209686,0.0001884814,0.993148,0.0007745778,0.0001197468,0.005564353],"study_design_scores_gemma":[0.000007544386,0.00006801749,0.0001619132,0.000002308737,0.000003921901,0.0000966706,0.000008271281,0.0008119121,0.9939658,0.0001614432,0.004707033,0.000005153796],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8353233,0.004533113,0.1439504,0.000791137,0.0006017758,0.000307337,0.0008493839,0.001904738,0.01173893],"genre_scores_gemma":[0.9282292,0.002185396,0.05393641,0.0005091228,0.00008972917,0.0002138414,0.0009644482,0.0001315089,0.01374027],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009384316,"threshold_uncertainty_score":0.003139436,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005863501298152543,"score_gpt":0.255883672961082,"score_spread":0.2500201716629294,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}