{"id":"W2022021861","doi":"10.1016/j.ceca.2007.01.002","title":"Protein kinase C decreases the apparent affinity of the inositol 1,4,5-trisphosphate receptor type 3 in RINm5F cells","year":2007,"lang":"en","type":"article","venue":"Cell Calcium","topic":"Protein Kinase Regulation and GTPase Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Sherbrooke","funders":"Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Heart and Stroke Foundation of Canada","keywords":"Protein kinase C; Gene isoform; Inositol trisphosphate receptor; Gq alpha subunit; Inositol; Phosphorylation; Receptor; Inositol trisphosphate; Cell biology; Phospholipase C; Biology; Biochemistry; Chemistry; G protein","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004526158,0.0008196543,0.0006782386,0.0007238163,0.0005086234,0.000985226,0.001263095,0.00105777,0.004507736],"category_scores_gemma":[0.0005374277,0.0004345669,0.000878445,0.0005653339,0.0008102198,0.0004703431,0.0003700875,0.00216113,0.001224302],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001611874,"about_ca_system_score_gemma":0.0009373481,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00989897,"about_ca_topic_score_gemma":0.007458169,"domain_scores_codex":[0.9994336,0.00008036894,0.00007824574,0.00009060094,0.0001469031,0.0001702118],"domain_scores_gemma":[0.9993765,0.0002056276,0.00007859462,0.0001371342,0.00005483148,0.0001473021],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001999862,0.00004919295,0.0001129062,0.00002969912,0.00001208808,0.00007413725,0.00001989976,0.00007732734,0.9985625,0.000276649,0.0001994746,0.0003860844],"study_design_scores_gemma":[0.00004189599,0.0001007913,0.003793936,0.00000502407,0.000022527,0.000252511,0.00005266147,0.001704921,0.992042,0.00005761562,0.001915961,0.00001024577],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9896321,0.001636705,0.002288801,0.0007719483,0.0001666381,0.00003200082,0.002099414,0.0003663649,0.00300588],"genre_scores_gemma":[0.9898465,0.0007121988,0.001943364,0.0002352101,0.00003529931,0.00006365302,0.002326428,0.000147848,0.004689558],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00989897,"threshold_uncertainty_score":0.01968271,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01361455753970478,"score_gpt":0.2481005109738927,"score_spread":0.2344859534341879,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}