{"id":"W2022021861","doi":"10.1016/j.ceca.2007.01.002","title":"Protein kinase C decreases the apparent affinity of the inositol 1,4,5-trisphosphate receptor type 3 in RINm5F cells","year":2007,"lang":"en","type":"article","venue":"Cell Calcium","topic":"Protein Kinase Regulation and GTPase Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Sherbrooke","funders":"Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Heart and Stroke Foundation of Canada","keywords":"Protein kinase C; Gene isoform; Inositol trisphosphate receptor; Gq alpha subunit; Inositol; Phosphorylation; Receptor; Inositol trisphosphate; Cell biology; Phospholipase C; Biology; Biochemistry; Chemistry; G protein","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004264762,0.0001360686,0.0001173196,0.00002919468,0.00008264741,0.00001225023,0.0002681169,0.0001233251,0.00004872765],"category_scores_gemma":[0.00007024534,0.00008729194,0.0000995023,0.0002388537,0.0001122763,0.000002733834,0.0001100657,0.0001292694,0.00001208181],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002204629,"about_ca_system_score_gemma":0.00009401294,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008537117,"about_ca_topic_score_gemma":0.00006493767,"domain_scores_codex":[0.999003,0.0001012724,0.000271428,0.0002190657,0.0001669676,0.0002382465],"domain_scores_gemma":[0.9992594,0.0000222479,0.0001390173,0.0004171757,0.00009199674,0.00007022464],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000170086,0.0001575516,0.001242363,0.00003330889,0.000006640817,0.000002113788,0.00004818581,0.00008894164,0.9969146,0.00006276467,0.0005713704,0.0007020562],"study_design_scores_gemma":[0.0003783737,0.00007418076,0.002006713,0.00003462008,0.000008556937,7.660704e-7,0.00006865142,0.00002693662,0.9660015,0.00002724855,0.03126019,0.0001122463],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962074,0.001736334,0.0005088786,0.00009300982,0.0002123654,0.0006137867,0.00000886561,0.000007389015,0.000611942],"genre_scores_gemma":[0.9989056,0.00003846371,0.0002730098,0.0001173046,0.0001119113,0.00002048594,0.00001922536,0.00001468348,0.0004993165],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0309131,"threshold_uncertainty_score":0.3559662,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01361455753970478,"score_gpt":0.2481005109738927,"score_spread":0.2344859534341879,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}