{"id":"W2022025213","doi":"10.1073/pnas.0507313103","title":"AMPA receptor downscaling at the onset of Alzheimer’s disease pathology in double knockin mice","year":2006,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Neuroscience and Neuropharmacology Research","field":"Neuroscience","cited_by":226,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Neurological Disorders and Stroke; National Eye Institute; York University; American Federation for Aging Research","keywords":"AMPA receptor; Neuroscience; Presenilin; Synaptic plasticity; Long-term potentiation; Synapse; Postsynaptic potential; Synaptic scaling; Biology; Glutamate receptor; Synaptic fatigue; Alzheimer's disease; Metaplasticity; Receptor; Disease; Medicine; Pathology; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["sts"],"consensus_categories":[],"category_scores_codex":[0.001699382,0.0001072579,0.0001709795,0.0002531113,0.0003449782,0.00001995633,0.00144966,0.0000546022,0.00004814072],"category_scores_gemma":[0.0008308722,0.00006333569,0.00008413423,0.00166308,0.00354622,0.0003598535,0.0004241295,0.0002814488,0.000006147995],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002765593,"about_ca_system_score_gemma":0.00007408446,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001514717,"about_ca_topic_score_gemma":3.189149e-7,"domain_scores_codex":[0.9974641,0.0000578354,0.0004347735,0.0004447125,0.00129447,0.0003040667],"domain_scores_gemma":[0.9988714,0.0005204132,0.0004216743,0.0000183269,0.0001214541,0.00004669352],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001093245,0.00009649277,0.01222777,0.00001590828,8.497209e-7,1.622102e-7,0.00004938809,0.0002133305,0.9810945,0.005349161,0.0007962307,0.00004690373],"study_design_scores_gemma":[0.0002876363,0.00003779231,0.05438142,0.00002397098,0.000007627598,0.0000163015,0.00002073817,0.0003846732,0.9405687,0.003943293,0.0002678186,0.00006002565],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.990881,0.0001165366,6.209397e-8,0.007160205,0.00005673955,0.0003237018,0.00003795431,0.000007965115,0.001415856],"genre_scores_gemma":[0.9986649,0.00006753254,0.0000250378,0.0007900728,0.00004211403,0.0000232712,5.544948e-8,0.000004681877,0.0003823727],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04215365,"threshold_uncertainty_score":0.9991655,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1029722899384386,"score_gpt":0.3760507205675122,"score_spread":0.2730784306290736,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}