{"id":"W2022028441","doi":"10.1067/mcp.2001.112513","title":"Pharmacokinetic interaction between single oral doses of ditiazem and sirolimus in healthy volunteers*1","year":2001,"lang":"en","type":"article","venue":"Clinical Pharmacology & Therapeutics","topic":"Renal Transplantation Outcomes and Treatments","field":"Medicine","cited_by":76,"is_retracted":false,"has_abstract":true,"ca_institutions":"Women's Health Research Institute","funders":"","keywords":"Diltiazem; Sirolimus; Pharmacokinetics; Crossover study; Pharmacology; Half-life; Medicine; Drug interaction; Volume of distribution; Chemistry; Internal medicine; Calcium","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001996939,0.0001477448,0.0004875363,0.0001146844,0.00003009955,0.000004728166,0.00005931356,0.0001268923,0.0002097762],"category_scores_gemma":[0.000006269723,0.0001221844,0.0001058877,0.0001609431,0.0001968143,0.0000618027,0.0000172388,0.0003414472,0.0000133962],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004369898,"about_ca_system_score_gemma":0.00003973995,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000236543,"about_ca_topic_score_gemma":0.000008489795,"domain_scores_codex":[0.9985707,0.0001926223,0.000659266,0.0002374868,0.0001142811,0.0002256358],"domain_scores_gemma":[0.9989371,0.0006415065,0.0001324989,0.00008801674,0.00005722571,0.00014365],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.004142391,0.001414967,0.953604,0.0001177709,0.0006840855,0.0001152617,0.0001630956,0.00001410987,0.00727789,0.000003042156,0.00007496586,0.03238839],"study_design_scores_gemma":[0.02048719,0.004350245,0.9576514,0.0001243316,0.002203854,0.0001059153,0.00007618055,0.0009639392,0.003692387,0.00008726331,0.0100802,0.0001770243],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9939505,0.0005272015,0.000104446,0.004167581,0.0005945837,0.0003396859,0.00001434431,0.00002671502,0.0002749566],"genre_scores_gemma":[0.9811873,0.004779025,0.0002588326,0.01342547,0.0002247074,0.000009287398,0.00003100092,0.00001772972,0.00006661342],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03221136,"threshold_uncertainty_score":0.4982537,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1855441911163117,"score_gpt":0.4851331775394629,"score_spread":0.2995889864231513,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}