{"id":"W2022046439","doi":"10.1089/cbr.2009.0714","title":"Tumor Necrosis Factor Gene-Engineered J558 Tumor Cell–Released Exosomes Stimulate Tumor Antigen P1A-Specific CD8 <sup>+</sup> CTL Responses and Antitumor Immunity","year":2010,"lang":"en","type":"article","venue":"Cancer Biotherapy and Radiopharmaceuticals","topic":"Extracellular vesicles in disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"Saskatchewan Cancer Agency","funders":"Canadian Institutes of Health Research","keywords":"CTL*; Cytotoxic T cell; CD8; Tumor antigen; Molecular biology; Immune system; Antigen; Tumor necrosis factor alpha; Biology; T cell; Immunology; Immunotherapy; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001104024,0.0003997729,0.0001997621,0.0000985611,0.00006655284,0.0003167179,0.00007869644,0.0002181828,0.0007789711],"category_scores_gemma":[0.0001082044,0.00009115489,0.0002769455,0.00008401414,0.0001502367,0.0002993165,0.0001864816,0.0005743811,0.0002796028],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001896275,"about_ca_system_score_gemma":0.0001022218,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001195717,"about_ca_topic_score_gemma":0.0001449666,"domain_scores_codex":[0.9998572,0.00002219108,0.000017133,0.00002838992,0.00002669739,0.00004835472],"domain_scores_gemma":[0.9999127,0.00002326262,0.00002547999,0.00001082563,0.000007202605,0.00002053393],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002437431,0.00008115514,0.0001945806,0.00002498838,0.000004824062,0.000040803,0.00001137277,0.00006649112,0.9982787,0.00004736844,0.00003417308,0.0009717028],"study_design_scores_gemma":[0.00003089228,0.0008009433,0.00306496,0.000004659239,0.000015089,0.0001804477,0.00002590649,0.001134828,0.9937965,0.0000316006,0.0009113358,0.000002996663],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983223,0.0002554566,0.0006876621,0.00003115755,0.00001857171,0.0000152,0.00008499567,0.00001539072,0.00056931],"genre_scores_gemma":[0.9975659,0.00020589,0.0009382736,0.00004141352,0.00001219002,0.00001991031,0.0002483733,0.00000899856,0.0009589059],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007789711,"threshold_uncertainty_score":0.002605915,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01851142871859519,"score_gpt":0.3024945320098232,"score_spread":0.2839831032912281,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}