{"id":"W2022046439","doi":"10.1089/cbr.2009.0714","title":"Tumor Necrosis Factor Gene-Engineered J558 Tumor Cell–Released Exosomes Stimulate Tumor Antigen P1A-Specific CD8 <sup>+</sup> CTL Responses and Antitumor Immunity","year":2010,"lang":"en","type":"article","venue":"Cancer Biotherapy and Radiopharmaceuticals","topic":"Extracellular vesicles in disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"Saskatchewan Cancer Agency","funders":"Canadian Institutes of Health Research","keywords":"CTL*; Cytotoxic T cell; CD8; Tumor antigen; Molecular biology; Immune system; Antigen; Tumor necrosis factor alpha; Biology; T cell; Immunology; Immunotherapy; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003628698,0.0006289502,0.0005682721,0.0001576918,0.0004045674,0.0001992736,0.0004622167,0.0002188496,0.0004708866],"category_scores_gemma":[0.00008430197,0.0005825775,0.0002100492,0.0002309138,0.0008576428,0.00003907229,0.0001422923,0.0005713282,0.00001200624],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003664762,"about_ca_system_score_gemma":0.0002405466,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003478699,"about_ca_topic_score_gemma":0.000003544761,"domain_scores_codex":[0.997145,0.0002721109,0.0005416039,0.0009813063,0.0002752728,0.0007847133],"domain_scores_gemma":[0.9980345,0.0001296358,0.0001818974,0.0008025343,0.0001292936,0.0007220931],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001547664,0.0002269735,0.007280496,0.0001433904,0.0001651543,0.0001122263,0.0001602676,0.00006398268,0.987286,0.00003104107,0.0005350997,0.002447742],"study_design_scores_gemma":[0.003512449,0.0002214183,0.01291596,0.00004329848,0.00006920273,0.0001099649,0.00005599889,0.001586025,0.9159603,0.00003143997,0.06469924,0.0007947613],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.947763,0.04973844,0.0002035477,0.0003262702,0.0003756575,0.0007234595,0.0007495718,0.00008503347,0.00003500627],"genre_scores_gemma":[0.9769318,0.01868423,0.001497176,0.001623015,0.0006164017,0.0000845232,0.00005932723,0.0001333538,0.0003701973],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07132572,"threshold_uncertainty_score":0.9996626,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01851142871859519,"score_gpt":0.3024945320098232,"score_spread":0.2839831032912281,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}