{"id":"W2022061101","doi":"10.1021/bi101480z","title":"Efavirenz Binding Site in HIV-1 Reverse Transcriptase Monomers","year":2010,"lang":"en","type":"article","venue":"Biochemistry","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Institute of General Medical Sciences","keywords":"Efavirenz; Reverse transcriptase; Human immunodeficiency virus (HIV); Virology; Chemistry; Binding site; Reverse-transcriptase inhibitor; Biology; RNA; Biochemistry; Viral load; Antiretroviral therapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001223846,0.0002534051,0.0002343605,0.0002024506,0.0003033743,0.0002660699,0.0003684816,0.0004054518,0.002120452],"category_scores_gemma":[0.0002638718,0.000149505,0.0001553029,0.0001907733,0.0001400851,0.0003026348,0.0001632558,0.0004544721,0.0007278225],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002883507,"about_ca_system_score_gemma":0.0001296573,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000637088,"about_ca_topic_score_gemma":0.0004822476,"domain_scores_codex":[0.9998245,0.00001661169,0.000005652664,0.00006039607,0.00006304977,0.00002995091],"domain_scores_gemma":[0.9999344,0.00001683422,0.00001597256,0.000008188023,0.00001089293,0.00001375823],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003004551,0.00005442518,0.0008320072,0.00008215748,0.00001126721,0.0002688617,0.00006118324,0.0003698801,0.9890984,0.0005813364,0.0002489293,0.008091117],"study_design_scores_gemma":[0.00003459688,0.0002754661,0.01034288,0.00002379575,0.00001739255,0.0009669993,0.00006879924,0.003746525,0.973924,0.0004951846,0.01008547,0.00001893393],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9836393,0.00362472,0.005578946,0.0001221111,0.00004628621,0.00003510844,0.0007314433,0.0000919119,0.006130015],"genre_scores_gemma":[0.9907884,0.0008943675,0.003688328,0.000122629,0.00000971728,0.00002488413,0.0009519248,0.00002089117,0.003498931],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002120452,"threshold_uncertainty_score":0.007093668,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007364695116959684,"score_gpt":0.2362246815979191,"score_spread":0.2288599864809594,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}