{"id":"W2022076467","doi":"10.1016/j.radonc.2011.05.059","title":"Hypoxia disrupts the Fanconi anemia pathway and sensitizes cells to chemotherapy through regulation of UBE2T","year":2011,"lang":"en","type":"article","venue":"Radiotherapy and Oncology","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":40,"is_retracted":false,"has_abstract":false,"ca_institutions":"University Health Network; University of Toronto; Ontario Institute for Cancer Research","funders":"Terry Fox Research Institute; Transnationale Universiteit Limburg; Canadian Institutes of Health Research; KWF Kankerbestrijding; Ontario Ministry of Health and Long-Term Care; Ontario Institute for Cancer Research","keywords":"FANCD2; Fanconi anemia; Cancer research; Hypoxia (environmental); Biology; DNA repair; Gene knockdown; RAD51; Ubiquitin ligase; Cell culture; Cell biology; Molecular biology; Chemistry; Ubiquitin; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002092253,0.0001418478,0.0002144751,0.00002240381,0.0000670622,0.000007206535,0.00009543547,0.0002011909,0.00004234708],"category_scores_gemma":[0.000009616857,0.0001053478,0.00004531217,0.0000568108,0.000167602,0.000005474178,0.00003432883,0.00005835255,0.000001048746],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002281042,"about_ca_system_score_gemma":0.00004535843,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003981261,"about_ca_topic_score_gemma":0.00005636218,"domain_scores_codex":[0.9992033,0.00008805229,0.0001812679,0.0002872956,0.00006286534,0.0001772111],"domain_scores_gemma":[0.9995055,0.0000328908,0.00009427404,0.0002719552,0.00003918817,0.00005621203],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000335782,0.0000470963,0.0002141769,0.00001195838,0.000046105,0.000002622133,0.002350528,0.000003328875,0.9684364,0.0008793309,0.000445431,0.02722721],"study_design_scores_gemma":[0.0008901711,0.001433208,0.005580849,0.000006928718,0.00001130367,0.00006650009,0.00019952,0.00004073381,0.9413434,0.000832531,0.04945154,0.0001433274],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.993637,0.00126596,0.003128162,0.0003983031,0.0001593955,0.0003149483,0.000008965393,0.00001303611,0.001074264],"genre_scores_gemma":[0.9838415,0.001526726,0.01203822,0.001989889,0.0001554568,0.00001650417,0.000006203077,0.00002532408,0.0004001815],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04900612,"threshold_uncertainty_score":0.429596,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01358772102990444,"score_gpt":0.2540221333723257,"score_spread":0.2404344123424213,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}