{"id":"W2022088290","doi":"10.1210/en.2008-0547","title":"Up-Regulation of 3′5′-Cyclic Guanosine Monophosphate-Specific Phosphodiesterase in the Porcine Cumulus-Oocyte Complex Affects Steroidogenesis during in Vitro Maturation","year":2008,"lang":"en","type":"article","venue":"Endocrinology","topic":"Phosphodiesterase function and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"","keywords":"Zaprinast; Phosphodiesterase; Internal medicine; Cyclic guanosine monophosphate; Endocrinology; PDE10A; Oocyte; Guanosine; In vitro maturation; Chemistry; cGMP-specific phosphodiesterase type 5; In vitro; Sildenafil; Gonadotropin; Biology; Enzyme; Cell biology; Biochemistry; Medicine; Nitric oxide","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001071155,0.0002151571,0.0002791898,0.000182549,0.0001070507,0.00001015743,0.0001752451,0.0001271189,0.00003477412],"category_scores_gemma":[0.00002856213,0.0001802035,0.00007887741,0.0002755613,0.0001479499,0.0000191817,0.00007334091,0.000121772,0.00000775794],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005102972,"about_ca_system_score_gemma":0.00002769449,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007380437,"about_ca_topic_score_gemma":0.0001090884,"domain_scores_codex":[0.9984896,0.0002024212,0.0004288207,0.0003788886,0.0001555862,0.0003446614],"domain_scores_gemma":[0.9992833,0.00003778406,0.0001848485,0.0004061062,0.0000541376,0.00003384628],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002555648,0.000118239,0.01030397,0.00002469109,0.00001615051,0.00003030437,0.0003961589,0.001040353,0.9839549,0.00004057253,0.0003135746,0.00120545],"study_design_scores_gemma":[0.00149031,0.00008834209,0.4548545,0.000008733426,0.000004427273,0.0001229765,0.000081917,0.0001686749,0.5415141,0.00001403404,0.00154151,0.0001104742],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968495,0.001659899,0.0002139837,0.0003550519,0.0003679165,0.0004015695,0.000009949007,0.00001670537,0.0001254121],"genre_scores_gemma":[0.9980314,0.0008107951,0.0001976823,0.0001532444,0.0001100497,0.00005843914,0.0003408327,0.00002073271,0.0002767787],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4445505,"threshold_uncertainty_score":0.7348486,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02489127115459665,"score_gpt":0.2438271377475853,"score_spread":0.2189358665929887,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}