{"id":"W2022088290","doi":"10.1210/en.2008-0547","title":"Up-Regulation of 3′5′-Cyclic Guanosine Monophosphate-Specific Phosphodiesterase in the Porcine Cumulus-Oocyte Complex Affects Steroidogenesis during in Vitro Maturation","year":2008,"lang":"en","type":"article","venue":"Endocrinology","topic":"Phosphodiesterase function and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"","keywords":"Zaprinast; Phosphodiesterase; Internal medicine; Cyclic guanosine monophosphate; Endocrinology; PDE10A; Oocyte; Guanosine; In vitro maturation; Chemistry; cGMP-specific phosphodiesterase type 5; In vitro; Sildenafil; Gonadotropin; Biology; Enzyme; Cell biology; Biochemistry; Medicine; Nitric oxide","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002012817,0.000282005,0.0004497611,0.0002062075,0.0002111909,0.0005189177,0.000189843,0.0003349725,0.000841236],"category_scores_gemma":[0.0002470364,0.0001837208,0.0004282397,0.0001290475,0.000317918,0.0002380339,0.000269808,0.0005452606,0.0002334962],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005236459,"about_ca_system_score_gemma":0.0003086572,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001206919,"about_ca_topic_score_gemma":0.001355182,"domain_scores_codex":[0.9997901,0.00003384954,0.00002365271,0.00004525502,0.00003970023,0.00006751466],"domain_scores_gemma":[0.9998084,0.00004765332,0.00003806283,0.00002294354,0.00001585409,0.0000672251],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000077458,0.00001123243,0.0001073746,0.00002529601,0.000002668925,0.00003027537,0.00001430524,0.00001127093,0.9994432,0.00002018652,0.00001574426,0.0002410847],"study_design_scores_gemma":[0.00002485598,0.0004301818,0.02030344,0.000008116721,0.00002806831,0.0001522779,0.00005181834,0.0007917077,0.975395,0.00003193096,0.002774123,0.00000844061],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9921934,0.003782339,0.001329548,0.0001903873,0.0001174487,0.00004791453,0.0004515691,0.00005326531,0.001834187],"genre_scores_gemma":[0.9941577,0.001313874,0.001454555,0.0001515665,0.00004703889,0.00005805271,0.0007900711,0.00002583265,0.002001384],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001206919,"threshold_uncertainty_score":0.003799319,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02489127115459665,"score_gpt":0.2438271377475853,"score_spread":0.2189358665929887,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}