{"id":"W2022093757","doi":"10.2174/1568011054866946","title":"Histone Deacetylase Inhibitors: Latest Developments, Trends and Prospects","year":2005,"lang":"en","type":"review","venue":"Current Medicinal Chemistry - Anti-Cancer Agents","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":83,"is_retracted":false,"has_abstract":true,"ca_institutions":"Pyrogenesis (Canada)","funders":"National Cancer Institute","keywords":"Histone deacetylase; Histone Acetyltransferases; Acetylation; HDAC11; Histone; Histone deacetylase 5; Histone deacetylase 2; Biochemistry; Vorinostat; Biology; Chemistry; Cancer research; Computational biology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007076147,0.0009407883,0.001301386,0.001535947,0.0002341124,0.0009387907,0.0009012672,0.0009368079,0.004585886],"category_scores_gemma":[0.000463233,0.0003119558,0.0003855379,0.001680477,0.0003940015,0.00158072,0.0004468905,0.001512605,0.003611041],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00060274,"about_ca_system_score_gemma":0.0006037741,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004636249,"about_ca_topic_score_gemma":0.001475154,"domain_scores_codex":[0.9998192,0.00002372485,0.00002204928,0.00003879784,0.00007606411,0.00002015858],"domain_scores_gemma":[0.9997949,0.00006407845,0.00003553188,0.000008239485,0.00006127595,0.00003606119],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000175739,0.00019439,0.0001500715,0.005656421,0.00005509502,0.0003467313,0.00004214986,0.0005045875,0.005755349,0.003336463,0.02474601,0.9590369],"study_design_scores_gemma":[0.00006368662,0.0002717102,0.0006068003,0.0009054418,0.0000702499,0.00159097,0.00004489378,0.0002125385,0.002431066,0.001612065,0.9921737,0.0000168661],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0003623758,0.9970241,0.0003520892,0.0003750591,0.0002701769,0.000008988589,0.00002149854,0.00001924836,0.001566358],"genre_scores_gemma":[0.001441167,0.995747,0.0006009699,0.000290645,0.000276709,0.00001092567,0.00004394176,0.000002491197,0.001586057],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.004585886,"threshold_uncertainty_score":0.01534134,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05549252155237416,"score_gpt":0.4098932568577817,"score_spread":0.3544007353054075,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}