{"id":"W2022093757","doi":"10.2174/1568011054866946","title":"Histone Deacetylase Inhibitors: Latest Developments, Trends and Prospects","year":2005,"lang":"en","type":"review","venue":"Current Medicinal Chemistry - Anti-Cancer Agents","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":83,"is_retracted":false,"has_abstract":true,"ca_institutions":"Pyrogenesis (Canada)","funders":"National Cancer Institute","keywords":"Histone deacetylase; Histone Acetyltransferases; Acetylation; HDAC11; Histone; Histone deacetylase 5; Histone deacetylase 2; Biochemistry; Vorinostat; Biology; Chemistry; Cancer research; Computational biology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003921032,0.001161553,0.001702125,0.0002377899,0.0002665502,0.00007468345,0.0007233317,0.0007753712,0.0004599307],"category_scores_gemma":[0.000162256,0.001065675,0.0004501954,0.0005827941,0.000533056,0.0000162264,0.0005928448,0.001170707,0.00006993393],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006319291,"about_ca_system_score_gemma":0.001218563,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001749558,"about_ca_topic_score_gemma":0.000008278046,"domain_scores_codex":[0.9950134,0.000116833,0.00114752,0.001726599,0.0009553168,0.00104033],"domain_scores_gemma":[0.9975863,0.00002452228,0.000622822,0.0008205939,0.0001972897,0.0007485445],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00002761638,0.0002977568,0.00007269336,0.01260921,0.0002927586,0.00004898414,0.00005914386,5.796472e-7,0.003352236,5.413053e-7,0.05893817,0.9243003],"study_design_scores_gemma":[0.001026894,0.00006370725,0.00002946929,0.008462105,0.0004336109,0.0001516389,0.000009809813,0.000003772843,0.01818647,2.943167e-7,0.9706364,0.0009958104],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0103492,0.9868476,0.000005352575,0.00007234841,0.000872434,0.0005676085,0.0003002288,0.00005422493,0.0009310019],"genre_scores_gemma":[0.002071303,0.9832273,0.00005551489,0.00003189147,0.003703347,0.0004398367,0.00249792,0.0001788161,0.007794083],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9233045,"threshold_uncertainty_score":0.9991794,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05549252155237416,"score_gpt":0.4098932568577817,"score_spread":0.3544007353054075,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}