{"id":"W2022109753","doi":"10.1021/jm200454y","title":"Discovery of 7-Hydroxy-6-methoxy-2-methyl-3-(3,4,5-trimethoxybenzoyl)benzo[<i>b</i>]furan (BNC105), a Tubulin Polymerization Inhibitor with Potent Antiproliferative and Tumor Vascular Disrupting Properties","year":2011,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Synthesis and biological activity","field":"Chemistry","cited_by":139,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre for Drug Research and Development","funders":"National Cancer Institute; National Institutes of Health","keywords":"Chemistry; Furan; Tubulin; Stereochemistry; Microtubule; Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000927191,0.0003665116,0.0008962733,0.00006116823,0.0001068752,0.00003746366,0.000280756,0.0001971149,0.0001263795],"category_scores_gemma":[0.0007918662,0.0002125359,0.0002295164,0.0001829277,0.0004514655,0.0003580711,0.00009466145,0.0006226714,4.230606e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006081866,"about_ca_system_score_gemma":0.0001750701,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006027905,"about_ca_topic_score_gemma":9.665104e-7,"domain_scores_codex":[0.9975813,0.0001126013,0.0009160817,0.0003536477,0.0007056862,0.0003306531],"domain_scores_gemma":[0.9978298,0.0002279276,0.001201234,0.0002449775,0.0002820275,0.0002140679],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001144505,0.000398365,0.01094613,0.0006431844,0.0002686604,0.00009921418,0.0006882615,0.000002393008,0.9813563,0.000004597302,0.000007320395,0.004441066],"study_design_scores_gemma":[0.001254432,0.0003525082,0.002523168,0.001253078,0.0002814014,0.0005502042,0.002755312,0.00009392233,0.9905546,0.00005270078,0.00004457989,0.000284132],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9943705,0.002704279,0.001297985,0.0001174751,0.00005231067,0.00008305404,0.000017534,0.00001792207,0.001338956],"genre_scores_gemma":[0.9966455,0.0002214372,0.002524558,0.00004974867,0.0004398712,0.000006200657,0.000004076551,0.00002895663,0.00007972707],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009198255,"threshold_uncertainty_score":0.8666962,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02307345293365503,"score_gpt":0.2168361442965784,"score_spread":0.1937626913629233,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}