{"id":"W2022109753","doi":"10.1021/jm200454y","title":"Discovery of 7-Hydroxy-6-methoxy-2-methyl-3-(3,4,5-trimethoxybenzoyl)benzo[<i>b</i>]furan (BNC105), a Tubulin Polymerization Inhibitor with Potent Antiproliferative and Tumor Vascular Disrupting Properties","year":2011,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Synthesis and biological activity","field":"Chemistry","cited_by":139,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre for Drug Research and Development","funders":"National Cancer Institute; National Institutes of Health","keywords":"Chemistry; Furan; Tubulin; Stereochemistry; Microtubule; Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009252687,0.0001877355,0.0001051547,0.0001132802,0.00006826027,0.0001003291,0.0001562073,0.0001554462,0.0007597712],"category_scores_gemma":[0.00006954564,0.00008341765,0.00008468804,0.00006584737,0.0001011211,0.0001228239,0.00007238641,0.0002421331,0.0002515837],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002119844,"about_ca_system_score_gemma":0.0002339067,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005439068,"about_ca_topic_score_gemma":0.001292725,"domain_scores_codex":[0.999971,0.000006599864,0.000001236469,0.000004806713,0.000008437934,0.000007870234],"domain_scores_gemma":[0.9999723,0.000002499669,0.000008835835,0.000001464692,0.000005714928,0.000009133805],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001142452,0.00009336352,0.0002263991,0.00006530635,0.000005278443,0.0001445157,0.00001678867,0.0005720802,0.9799244,0.0006518523,0.0002573983,0.01792837],"study_design_scores_gemma":[0.00009402128,0.001980598,0.003236966,0.00001349106,0.00001715493,0.0006187083,0.00001456474,0.002015034,0.978566,0.0001432138,0.01328891,0.00001147168],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9746202,0.007160476,0.01073388,0.000517137,0.00005380618,0.0001027229,0.0003580795,0.00008364733,0.006370032],"genre_scores_gemma":[0.9870936,0.003184466,0.005910714,0.0001135908,0.00001804124,0.00002600728,0.0003374255,0.000007139769,0.003308933],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007597712,"threshold_uncertainty_score":0.002541721,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02307345293365503,"score_gpt":0.2168361442965784,"score_spread":0.1937626913629233,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}