{"id":"W2022152619","doi":"10.1021/jo100391e","title":"Ligand-Controlled Selectivity in the Desymmetrization of <i>meso</i> Cyclopenten-1,4-diols via Rhodium(I)-Catalyzed Addition of Arylboronic Acids","year":2010,"lang":"en","type":"article","venue":"The Journal of Organic Chemistry","topic":"Asymmetric Synthesis and Catalysis","field":"Chemistry","cited_by":52,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Desymmetrization; Chemistry; Rhodium; Enantioselective synthesis; Ligand (biochemistry); Selectivity; Catalysis; Allylic rearrangement; Yield (engineering); Stereochemistry; Medicinal chemistry; Organic chemistry; Combinatorial chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001591638,0.0005880839,0.0002243154,0.0001264115,0.0001081885,0.0002474668,0.0003091976,0.0002158364,0.001147276],"category_scores_gemma":[0.0001742086,0.0002061508,0.0001715295,0.0001200543,0.0002283758,0.0002492644,0.0002320235,0.0004356634,0.0006465683],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002496923,"about_ca_system_score_gemma":0.0003369017,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007929792,"about_ca_topic_score_gemma":0.001782,"domain_scores_codex":[0.9998655,0.00002298057,0.00001090943,0.00003202828,0.00002197806,0.00004656355],"domain_scores_gemma":[0.9999095,0.00001407418,0.00003010079,0.000014403,0.00001214857,0.0000197105],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001432045,0.00002196628,0.000131708,0.00008035912,0.000007220275,0.0001238007,0.00004710124,0.0002565407,0.9947589,0.0005278654,0.0001545464,0.003746778],"study_design_scores_gemma":[0.00001078105,0.00005198619,0.000193231,0.000001644334,0.000004226151,0.0000759337,0.000007505488,0.0002126439,0.9981641,0.00002067162,0.001252686,0.000004427748],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9743569,0.001099497,0.01031772,0.0002362789,0.00007520892,0.00007653241,0.0004281007,0.0003252394,0.01308444],"genre_scores_gemma":[0.9928925,0.0008208199,0.003309034,0.00004360732,0.00001158647,0.00001914446,0.0001800602,0.00005784065,0.002665362],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001147276,"threshold_uncertainty_score":0.003838003,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00467367082155919,"score_gpt":0.2039821991119264,"score_spread":0.1993085282903672,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}