{"id":"W2022159376","doi":"10.1016/j.bmc.2013.09.024","title":"Synthetic trimethyllysine receptors that bind histone 3, trimethyllysine 27 (H3K27me3) and disrupt its interaction with the epigenetic reader protein CBX7","year":2013,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":41,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Victoria","funders":"Natural Sciences and Engineering Research Council of Canada; Prostate Cancer Canada","keywords":"Chemistry; Histone; Histone H3; Acetylation; Epigenetics; Methylation; Lysine; Biochemistry; Transcription (linguistics); Gene silencing; Protein–protein interaction; Gene; Cell biology; Amino acid; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004581979,0.0004230139,0.0003577904,0.00005522896,0.0001902221,0.00006886118,0.0003038473,0.0003156944,0.0005170534],"category_scores_gemma":[0.0002874967,0.0002845518,0.00008941775,0.0002789402,0.0003453589,0.00001740817,0.0001257439,0.0003504685,0.00004108646],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007032279,"about_ca_system_score_gemma":0.0001523289,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008624929,"about_ca_topic_score_gemma":0.00001093736,"domain_scores_codex":[0.9978806,0.0001344964,0.0003922887,0.0007387213,0.0004227572,0.0004311857],"domain_scores_gemma":[0.9984914,0.00006934999,0.0003086783,0.0006599169,0.0002219258,0.000248712],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001214323,0.0000821236,0.0003543781,0.00008674831,0.0001008706,0.000003463671,0.0001207257,0.00000309539,0.9913312,0.000001677827,0.0006924407,0.007101873],"study_design_scores_gemma":[0.0009080113,0.0003593224,0.001633278,0.00009626944,0.0001557635,0.00004863976,0.0005725615,0.00004061374,0.9780614,0.00002954536,0.01772115,0.0003734433],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9827251,0.01184944,0.0009812074,0.002655931,0.0001810244,0.0006869922,0.00000762187,0.00003091447,0.000881792],"genre_scores_gemma":[0.9913231,0.000699038,0.0003499754,0.0001237136,0.0005021265,0.00008380225,0.0001272868,0.00007201233,0.006718966],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0170287,"threshold_uncertainty_score":0.9999607,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01312667953036182,"score_gpt":0.2503801819172454,"score_spread":0.2372535023868836,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}