{"id":"W2022159376","doi":"10.1016/j.bmc.2013.09.024","title":"Synthetic trimethyllysine receptors that bind histone 3, trimethyllysine 27 (H3K27me3) and disrupt its interaction with the epigenetic reader protein CBX7","year":2013,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":41,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Victoria","funders":"Natural Sciences and Engineering Research Council of Canada; Prostate Cancer Canada","keywords":"Chemistry; Histone; Histone H3; Acetylation; Epigenetics; Methylation; Lysine; Biochemistry; Transcription (linguistics); Gene silencing; Protein–protein interaction; Gene; Cell biology; Amino acid; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001889941,0.0002572886,0.0002015192,0.0001221862,0.0001208891,0.0003126769,0.0006178769,0.0003615023,0.002120375],"category_scores_gemma":[0.0001823744,0.0001588895,0.0001902409,0.0001049727,0.0002597292,0.0001929655,0.000232642,0.0004400283,0.000477906],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004672788,"about_ca_system_score_gemma":0.0002289577,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006801173,"about_ca_topic_score_gemma":0.001029072,"domain_scores_codex":[0.9998683,0.000019096,0.000007393036,0.00002598809,0.00003803111,0.00004119459],"domain_scores_gemma":[0.9999139,0.0000158702,0.00003117343,0.00001131681,0.000006266529,0.0000213399],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002720258,0.00004308886,0.0001563002,0.00003468663,0.00001962177,0.00004808776,0.0000108013,0.0003615471,0.9965558,0.0008316927,0.0001373982,0.001528933],"study_design_scores_gemma":[0.00003490786,0.0001611926,0.0002775825,0.000001531498,0.00001278049,0.00009884161,0.00001461781,0.0009460549,0.9967331,0.00007241013,0.001642002,0.000005041333],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9882692,0.001246195,0.006604496,0.0001610668,0.00008492383,0.00004644579,0.0002613327,0.0001495113,0.003176928],"genre_scores_gemma":[0.9935297,0.0004560796,0.002710913,0.0000854359,0.000006526282,0.00001946891,0.0002461001,0.00001998016,0.002925803],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002120375,"threshold_uncertainty_score":0.00709337,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01312667953036182,"score_gpt":0.2503801819172454,"score_spread":0.2372535023868836,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}