{"id":"W2022159597","doi":"10.1126/science.1236188","title":"Nuclear PTEN Controls DNA Repair and Sensitivity to Genotoxic Stress","year":2013,"lang":"en","type":"article","venue":"Science","topic":"PI3K/AKT/mTOR signaling in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":412,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; Ontario Institute for Cancer Research; University of Toronto","funders":"National Cancer Institute; Canadian Institutes of Health Research","keywords":"PTEN; Tensin; SUMO protein; Cancer research; DNA damage; Biology; Phosphatase; Tumor suppressor gene; PI3K/AKT/mTOR pathway; DNA repair; Cell biology; Ubiquitin; Molecular biology; Signal transduction; Phosphorylation; DNA; Gene; Carcinogenesis; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003526351,0.00008613511,0.00008383244,0.0000324217,0.0001373733,0.00006803274,0.0001360289,0.0000486461,0.00002960576],"category_scores_gemma":[0.0001859347,0.00007819432,0.00002866956,0.0001271039,0.0003255121,0.0000108861,0.0001892435,0.00004539963,0.00005146901],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001987225,"about_ca_system_score_gemma":0.00007251705,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005397109,"about_ca_topic_score_gemma":0.00002301683,"domain_scores_codex":[0.9990233,0.00002958489,0.00008659007,0.0004174017,0.0001733854,0.000269809],"domain_scores_gemma":[0.9993556,0.00001192451,0.00003103623,0.0003227469,0.0001136379,0.0001650973],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000007689757,0.000008931048,0.001693762,0.000003505595,0.000004432598,0.00000240419,0.00004799157,0.00003177175,0.9960206,0.00002802722,0.0005587735,0.001592068],"study_design_scores_gemma":[0.0002791795,0.0002553268,0.05429825,0.00002109879,0.000007123826,0.00002716533,0.00008613277,0.00167455,0.9306137,0.00007103326,0.01239424,0.0002721925],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998486,0.0001257949,0.0002071855,0.0002673481,0.0001235466,0.000203351,0.0000113822,0.00002603207,0.0005493155],"genre_scores_gemma":[0.9976389,0.00001037276,0.001022345,0.001007541,0.000108886,0.00001198091,0.000001338163,0.000008942285,0.0001896928],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06540694,"threshold_uncertainty_score":0.3188672,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005879961851486051,"score_gpt":0.2366991467382825,"score_spread":0.2308191848867965,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}