{"id":"W2022171667","doi":"10.1016/j.ejpb.2013.01.026","title":"Microneedle/nanoencapsulation-mediated transdermal delivery: Mechanistic insights","year":2013,"lang":"en","type":"article","venue":"European Journal of Pharmaceutics and Biopharmaceutics","topic":"Advancements in Transdermal Drug Delivery","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":50,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Alexandria University; Queen's University; Biotechnology and Biological Sciences Research Council; Invest Northern Ireland","keywords":"Transdermal; Permeation; Zeta potential; PLGA; Fluorescein; Chemistry; Nanoparticle; Rhodamine; Rhodamine B; Nanotechnology; Biophysics; Materials science; Organic chemistry; Pharmacology; Fluorescence; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001386671,0.0006362196,0.0006275099,0.000470448,0.0004682738,0.0001331174,0.0007478422,0.0002012173,0.001816696],"category_scores_gemma":[0.00009246081,0.0005725421,0.0002595783,0.0004778131,0.0005449698,0.000697585,0.0001774761,0.001948116,0.0004937058],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001150855,"about_ca_system_score_gemma":0.0001327841,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000482133,"about_ca_topic_score_gemma":8.897748e-7,"domain_scores_codex":[0.9951024,0.001420254,0.00159205,0.0004541909,0.0005722184,0.0008588955],"domain_scores_gemma":[0.9965925,0.0005169724,0.0008116445,0.0002443179,0.0007651702,0.00106937],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0005257983,0.0006677761,0.001153164,0.0002093584,0.0008251021,0.0008873147,0.001611539,0.001168875,0.905684,0.000333884,0.002510134,0.08442306],"study_design_scores_gemma":[0.01406486,0.0007878312,0.002376321,0.0001556012,0.001706805,0.0009513986,0.001014767,0.05002374,0.2582913,0.0005154057,0.6686098,0.001502162],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9743131,0.01112206,0.004976635,0.001482696,0.003361111,0.0009102024,0.0001185181,0.0001254449,0.003590163],"genre_scores_gemma":[0.9780556,0.01342194,0.002173082,0.005143512,0.0007752541,0.000007526003,0.00002962029,0.0001159217,0.0002775751],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6660997,"threshold_uncertainty_score":0.9996726,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07248460278221977,"score_gpt":0.3616184309528268,"score_spread":0.289133828170607,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}