{"id":"W2022202320","doi":"10.1074/jbc.m110.198754","title":"Neutralization of Clostridium difficile Toxin A with Single-domain Antibodies Targeting the Cell Receptor Binding Domain","year":2011,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Clostridium difficile and Clostridium perfringens research","field":"Medicine","cited_by":154,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph; University of Calgary; Carleton University; National Research Council Canada; Institute for Biological Sciences; Alberta Glycomics Centre; University of Ottawa","funders":"","keywords":"Neutralization; Epitope; Clostridium difficile toxin A; Toxin; Clostridium difficile toxin B; Antibody; Clostridium difficile; Microbiology; Conformational epitope; Phage display; Epitope mapping; Immune system; Receptor; Virology; Chemistry; Biology; Molecular biology; Biochemistry; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000189529,0.0005700926,0.0002492204,0.0002101486,0.0001037011,0.000190529,0.000188241,0.0003517554,0.0006119617],"category_scores_gemma":[0.0001526452,0.0001607595,0.0003384363,0.0001793107,0.0001248887,0.0001358972,0.0002179167,0.0004323779,0.0002095933],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002245602,"about_ca_system_score_gemma":0.0001521048,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006095033,"about_ca_topic_score_gemma":0.0005878214,"domain_scores_codex":[0.9997813,0.00005217446,0.00001635663,0.00003633081,0.00005422828,0.00005967672],"domain_scores_gemma":[0.999923,0.00002184916,0.00001543517,0.00001057814,0.00001218782,0.00001702009],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006048207,0.00006749231,0.0001016939,0.0000156573,0.00000660615,0.00001447062,0.000005018715,0.00008766341,0.9984113,0.00001366551,0.00001325879,0.001202583],"study_design_scores_gemma":[0.00005503991,0.002993367,0.004061962,0.000006420728,0.00002756194,0.0002905827,0.00001293915,0.001348027,0.9898894,0.00002407889,0.001285192,0.000005403439],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967116,0.000682039,0.001863752,0.00002015632,0.00001441005,0.0000323076,0.00006563246,0.00002505843,0.0005850601],"genre_scores_gemma":[0.9956931,0.0005406016,0.002400484,0.00006420007,0.00001135454,0.00002220122,0.0003287584,0.000008547146,0.0009306479],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006119617,"threshold_uncertainty_score":0.002047241,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04329976945888487,"score_gpt":0.2618836786979981,"score_spread":0.2185839092391132,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}