{"id":"W2022202320","doi":"10.1074/jbc.m110.198754","title":"Neutralization of Clostridium difficile Toxin A with Single-domain Antibodies Targeting the Cell Receptor Binding Domain","year":2011,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Clostridium difficile and Clostridium perfringens research","field":"Medicine","cited_by":154,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph; University of Calgary; Carleton University; National Research Council Canada; Institute for Biological Sciences; Alberta Glycomics Centre; University of Ottawa","funders":"","keywords":"Neutralization; Epitope; Clostridium difficile toxin A; Toxin; Clostridium difficile toxin B; Antibody; Clostridium difficile; Microbiology; Conformational epitope; Phage display; Epitope mapping; Immune system; Receptor; Virology; Chemistry; Biology; Molecular biology; Biochemistry; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006621378,0.0002294383,0.0005285561,0.00006682729,0.0001117366,0.00002044631,0.0002891539,0.0002210005,0.0006018539],"category_scores_gemma":[0.0002687538,0.0001188119,0.0002423605,0.0003744763,0.0003590083,0.00005434167,0.00008703285,0.0005846499,0.000007109416],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001156653,"about_ca_system_score_gemma":0.0001449716,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007845938,"about_ca_topic_score_gemma":4.411838e-7,"domain_scores_codex":[0.9980727,0.00009683078,0.0007523503,0.0002225561,0.0004685415,0.0003869522],"domain_scores_gemma":[0.9983904,0.0001884066,0.0006362987,0.0002243465,0.000372469,0.0001881191],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001316902,0.0006730622,0.005808328,0.0001585365,0.00007704734,0.00008307099,0.0003352097,0.000003411346,0.9905081,0.000008630489,0.0008665582,0.0001611108],"study_design_scores_gemma":[0.001236035,0.001288873,0.0003910639,0.0002145365,0.00005443539,0.0002076626,0.002785754,0.000004536106,0.9924652,0.00003424213,0.001173294,0.0001443988],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9951276,0.0006218377,0.0001242257,0.0003535007,0.00006207499,0.0001767937,0.00002565624,0.00001749189,0.003490833],"genre_scores_gemma":[0.9967224,0.0003223683,0.002357535,0.00003305806,0.0003638865,0.000003329765,0.00002820441,0.00001987087,0.000149318],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005417264,"threshold_uncertainty_score":0.6589878,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04329976945888487,"score_gpt":0.2618836786979981,"score_spread":0.2185839092391132,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}