{"id":"W2022215700","doi":"10.1007/s00262-013-1420-z","title":"Anti-tumor activity of a novel monoclonal antibody, NPC-1C, optimized for recognition of tumor antigen MUC5AC variant in preclinical models","year":2013,"lang":"en","type":"article","venue":"Cancer Immunology Immunotherapy","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":23,"is_retracted":false,"has_abstract":false,"ca_institutions":"Precision BioLogic (Canada)","funders":"Public Health Agency of Canada","keywords":"Antigen; Pancreatic tumor; Monoclonal antibody; Tumor antigen; Antibody; Pancreatic cancer; Cancer research; Flow cytometry; Immunohistochemistry; Tumor M2-PK; Biology; Pathology; Immunotherapy; Cancer; Medicine; Molecular biology; Colorectal cancer; Immunology; Immune system; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004590011,0.0004451881,0.0004582596,0.0004283546,0.0001995139,0.0003283579,0.0005202849,0.0004951491,0.0008508194],"category_scores_gemma":[0.0002552375,0.0001774979,0.0003043927,0.0002386297,0.0003376213,0.0003359825,0.0001213225,0.00118842,0.0002433565],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006858808,"about_ca_system_score_gemma":0.0007515283,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002678195,"about_ca_topic_score_gemma":0.003334708,"domain_scores_codex":[0.9997359,0.00004556697,0.00001567287,0.00004001493,0.00007066211,0.00009209276],"domain_scores_gemma":[0.9998251,0.00003416206,0.00003015068,0.00002421474,0.00004141699,0.00004509814],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009405736,0.0006403584,0.0001726333,0.00007970598,0.00001668166,0.00004750605,0.00002102916,0.0007159234,0.9932171,0.0001171003,0.0002203187,0.003811188],"study_design_scores_gemma":[0.0001046689,0.004260467,0.001151967,0.000006380102,0.00004918488,0.0001549472,0.00001161824,0.001791343,0.9910034,0.00003373986,0.001425579,0.000006716653],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9942794,0.001773587,0.002016625,0.00009907032,0.00005835608,0.00006804856,0.0003238527,0.00009774436,0.001283473],"genre_scores_gemma":[0.9935859,0.001319542,0.001759132,0.00005174158,0.00001931573,0.00006658403,0.0007732797,0.0000204077,0.002404117],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002678195,"threshold_uncertainty_score":0.005325258,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05509080188052744,"score_gpt":0.3320206182949923,"score_spread":0.2769298164144648,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}