{"id":"W2022215700","doi":"10.1007/s00262-013-1420-z","title":"Anti-tumor activity of a novel monoclonal antibody, NPC-1C, optimized for recognition of tumor antigen MUC5AC variant in preclinical models","year":2013,"lang":"en","type":"article","venue":"Cancer Immunology Immunotherapy","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":23,"is_retracted":false,"has_abstract":false,"ca_institutions":"Precision BioLogic (Canada)","funders":"Public Health Agency of Canada","keywords":"Antigen; Pancreatic tumor; Monoclonal antibody; Tumor antigen; Antibody; Pancreatic cancer; Cancer research; Flow cytometry; Immunohistochemistry; Tumor M2-PK; Biology; Pathology; Immunotherapy; Cancer; Medicine; Molecular biology; Colorectal cancer; Immunology; Immune system; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001006483,0.0006319975,0.001955834,0.0006026295,0.0002034678,0.00002429905,0.0008910114,0.0006695003,0.00155135],"category_scores_gemma":[0.000181594,0.0005952956,0.0006125047,0.0004994037,0.001241477,0.0006582887,0.000129166,0.0007530524,0.00003957432],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001430912,"about_ca_system_score_gemma":0.0006429017,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003297198,"about_ca_topic_score_gemma":0.00001983356,"domain_scores_codex":[0.9956346,0.0007107052,0.001755753,0.0007911184,0.0001067926,0.001001094],"domain_scores_gemma":[0.9959956,0.001153267,0.001299798,0.0009544085,0.000568727,0.00002820715],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01371004,0.001983836,0.0006925175,0.0000805884,0.001849141,0.00000384651,0.0008187877,0.0002742058,0.9525408,0.0002055547,0.0001208955,0.02771983],"study_design_scores_gemma":[0.03362234,0.002014499,0.04965261,0.0005813666,0.0001072653,0.0002280259,0.0003319802,0.001388062,0.907395,0.001154182,0.002543668,0.000981005],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9426863,0.0406932,0.01179898,0.0003692345,0.00140617,0.002411629,0.0004604303,0.00008112549,0.00009293398],"genre_scores_gemma":[0.9834215,0.01072298,0.003665127,0.0003421946,0.00003673702,0.001180347,0.0002032794,0.0001200013,0.0003078438],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04896009,"threshold_uncertainty_score":0.9996498,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05509080188052744,"score_gpt":0.3320206182949923,"score_spread":0.2769298164144648,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}