{"id":"W2022221356","doi":"10.1073/pnas.1306262110","title":"De novo identification of VRC01 class HIV-1–neutralizing antibodies by next-generation sequencing of B-cell transcripts","year":2013,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":96,"is_retracted":false,"has_abstract":true,"ca_institutions":"Immunovaccine (Canada)","funders":"National Institutes of Health","keywords":"Immunoglobulin light chain; Antibody; Biology; Phylogenetic tree; Virology; Genetics; Peptide sequence; Sequence analysis; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001108781,0.00009927032,0.0002391594,0.000202269,0.0001277263,0.00002473736,0.0004051065,0.00008742724,0.00003096357],"category_scores_gemma":[0.0002291858,0.00006801332,0.0001147652,0.0005241906,0.0008524341,0.0005370094,0.00004842199,0.0001622317,0.000001753477],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004888436,"about_ca_system_score_gemma":0.00009216707,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009164534,"about_ca_topic_score_gemma":1.548068e-7,"domain_scores_codex":[0.9977598,0.0000127256,0.0006097931,0.0002011534,0.0012295,0.0001870052],"domain_scores_gemma":[0.9986165,0.00007468566,0.0005184893,0.00001320741,0.0007250997,0.00005206966],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002104323,0.00007122621,0.01429424,0.0004372588,0.00001587825,7.032751e-9,0.0004030823,0.00003331282,0.9778922,0.005409515,0.001180058,0.0002421603],"study_design_scores_gemma":[0.0002094579,0.0000708763,0.0344872,0.0001534784,0.00002325464,0.00001041046,0.000435007,0.005794564,0.9565723,0.002108499,0.0000765739,0.00005838502],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9923588,0.0004159328,0.000007998656,0.003824255,0.0000141086,0.0002735405,0.00003621076,0.000005749622,0.003063373],"genre_scores_gemma":[0.997459,0.0001993212,0.001305243,0.000147883,0.00006404743,0.000009704484,0.000002010408,0.000005065616,0.0008077457],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02131992,"threshold_uncertainty_score":0.3140829,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1214241207231475,"score_gpt":0.3386186928534321,"score_spread":0.2171945721302846,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}