{"id":"W2022224915","doi":"10.1177/108705710000500504","title":"Impact of a Red-Shifted Dye Label for High Throughput Fluorescence Polarization Assays of G Protein–Coupled Receptors","year":2000,"lang":"en","type":"article","venue":"SLAS DISCOVERY","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":52,"is_retracted":false,"has_abstract":false,"ca_institutions":"BioPhage Pharma (Canada)","funders":"","keywords":"Fluorescein; Tartrazine; Fluorescence anisotropy; Fluorescence; BODIPY; G protein-coupled receptor; Chemistry; High-throughput screening; Receptor; Biophysics; Chromatography; Biochemistry; Membrane; Biology; Optics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001762656,0.000167944,0.000243369,0.00003870308,0.00005215031,0.00002116891,0.0001690815,0.0001778176,0.0002546539],"category_scores_gemma":[0.00008908535,0.0001429114,0.0001794724,0.0001418172,0.00006160577,0.00002363582,0.0000328305,0.0000570681,0.000001670729],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002249256,"about_ca_system_score_gemma":0.0001396515,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002165199,"about_ca_topic_score_gemma":0.000009181303,"domain_scores_codex":[0.9989397,0.00004714516,0.0003292767,0.0003001787,0.0001596166,0.0002240896],"domain_scores_gemma":[0.9993497,0.00001345434,0.0001838478,0.0002915283,0.0001183577,0.00004315441],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004537909,0.0001398016,0.001060127,0.00004510333,0.0001044279,2.289055e-7,0.00003605729,0.0001337078,0.9950283,0.0008657377,0.0001335408,0.001999189],"study_design_scores_gemma":[0.001048337,0.001307392,0.001678187,0.00007912769,0.00003181053,0.000001064579,0.00002271875,0.0006051407,0.993511,0.001374738,0.000142255,0.0001982182],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9876803,0.0001831659,0.01124503,0.00002020695,0.00009692906,0.0005154646,0.000128863,0.000008947292,0.0001211184],"genre_scores_gemma":[0.9938323,0.00007940812,0.00449873,0.00001138857,0.0001092589,0.00003686083,0.0003831634,0.00003026618,0.001018634],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006746305,"threshold_uncertainty_score":0.5827757,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00952652462042239,"score_gpt":0.2569118775501559,"score_spread":0.2473853529297335,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}