{"id":"W2022237652","doi":"10.1021/np800579x","title":"Synthesis and Cytotoxicity of Bidesmosidic Betulin and Betulinic Acid Saponins","year":2008,"lang":"en","type":"article","venue":"Journal of Natural Products","topic":"Natural product bioactivities and synthesis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":94,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université du Québec à Chicoutimi","funders":"","keywords":"Betulin; Betulinic acid; Cytotoxicity; Saponin; Chemistry; Triterpene; Stereochemistry; Cytotoxic T cell; Traditional medicine; Biochemistry; In vitro; Biology; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008610191,0.0003695371,0.0002136797,0.000234781,0.0001275785,0.0001888997,0.0001141582,0.000134092,0.0006063764],"category_scores_gemma":[0.0001050195,0.00008199381,0.0001461375,0.0002292983,0.0001353955,0.0001568085,0.0001740768,0.0001913527,0.0001969543],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001300393,"about_ca_system_score_gemma":0.0001512114,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002377466,"about_ca_topic_score_gemma":0.00053252,"domain_scores_codex":[0.9999567,0.000007517971,0.000004189232,0.000007328977,0.00001464646,0.000009584311],"domain_scores_gemma":[0.9999489,0.000006954582,0.00001018385,0.000006481382,0.000008679262,0.00001884752],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008007971,0.00001496412,0.0001167619,0.00003894145,0.000004711463,0.00005299022,0.0000110097,0.0002246557,0.996712,0.0001040616,0.00001448125,0.002625397],"study_design_scores_gemma":[0.00001552713,0.0003867449,0.001403582,0.00000545304,0.00001613007,0.0001811589,0.00001295054,0.0002648976,0.9953957,0.00006033592,0.002253567,0.000003884285],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9936386,0.002188196,0.001862269,0.00002782509,0.00001651133,0.00004173521,0.0003237307,0.00002918615,0.00187195],"genre_scores_gemma":[0.9920649,0.001832133,0.003559863,0.00002945414,0.00001091294,0.00003973039,0.0005747136,0.00001015776,0.001878162],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006063764,"threshold_uncertainty_score":0.002028584,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01357516717227384,"score_gpt":0.229966955767109,"score_spread":0.2163917885948351,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}