{"id":"W2022237652","doi":"10.1021/np800579x","title":"Synthesis and Cytotoxicity of Bidesmosidic Betulin and Betulinic Acid Saponins","year":2008,"lang":"en","type":"article","venue":"Journal of Natural Products","topic":"Natural product bioactivities and synthesis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":94,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université du Québec à Chicoutimi","funders":"","keywords":"Betulin; Betulinic acid; Cytotoxicity; Saponin; Chemistry; Triterpene; Stereochemistry; Cytotoxic T cell; Traditional medicine; Biochemistry; In vitro; Biology; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000429904,0.0001717251,0.0003763719,0.00009653442,0.0001017352,0.00001173718,0.0001524789,0.0001326895,0.000004520155],"category_scores_gemma":[0.001549214,0.0001270154,0.00009630677,0.0001264265,0.000301797,0.00002533065,0.00009733494,0.0002651607,4.53569e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001150483,"about_ca_system_score_gemma":0.00009956125,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009052947,"about_ca_topic_score_gemma":0.000002899688,"domain_scores_codex":[0.998831,0.00009741985,0.0004095877,0.0002673572,0.0002102456,0.0001843821],"domain_scores_gemma":[0.9989515,0.00006687526,0.0004091288,0.0002139056,0.0002772753,0.00008133137],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002887457,0.00005246361,0.002314604,0.00006122861,0.0001217139,0.00001453755,0.00006392011,6.362809e-7,0.9901071,0.000007474166,0.001121795,0.005845762],"study_design_scores_gemma":[0.0002859958,0.0003488466,0.02376662,0.00004346703,0.000055182,0.0008762521,0.00005181615,0.000004212049,0.9732962,0.00004092806,0.001080981,0.0001495514],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9734893,0.02462533,0.00000513121,0.001517092,0.000218476,0.0000997247,0.00001153529,0.000003263183,0.00003008592],"genre_scores_gemma":[0.9925472,0.004848292,0.001818202,0.00008357406,0.0005173538,9.425822e-7,0.000002384142,0.00001501043,0.0001670708],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02145201,"threshold_uncertainty_score":0.5179538,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01357516717227384,"score_gpt":0.229966955767109,"score_spread":0.2163917885948351,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}