{"id":"W2022242801","doi":"10.1073/pnas.1217042110","title":"Structures of ABCB10, a human ATP-binding cassette transporter in apo- and nucleotide-bound states","year":2013,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":240,"is_retracted":false,"has_abstract":true,"ca_institutions":"Structural Genomics Consortium; University of Toronto","funders":"Biotechnology and Biological Sciences Research Council; Engineering and Physical Sciences Research Council; Canadian Institutes of Health Research; Wellcome Trust; GlaxoSmithKline; Pfizer","keywords":"ATP-binding cassette transporter; Transporter; Mitochondrion; Biophysics; Nucleotide; Biochemistry; Binding site; Chemistry; Biology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001660123,0.0005207823,0.0004734636,0.0003760956,0.0006520132,0.0007236507,0.0008502861,0.001321046,0.006398171],"category_scores_gemma":[0.000362159,0.0004143925,0.0003145087,0.0008833265,0.0003618195,0.0005809441,0.0002356361,0.001049927,0.0008418498],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001383281,"about_ca_system_score_gemma":0.000389429,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00762783,"about_ca_topic_score_gemma":0.007091044,"domain_scores_codex":[0.9998962,0.0000207084,0.000006463425,0.00001968183,0.00003536745,0.00002154754],"domain_scores_gemma":[0.9998633,0.00002877788,0.00002614834,0.000009363566,0.00003285841,0.00003952399],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.005769281,0.0009871399,0.02120823,0.002964334,0.000497868,0.007546613,0.002315662,0.02508432,0.7583408,0.03036386,0.09482298,0.05009892],"study_design_scores_gemma":[0.001910578,0.002104219,0.1455142,0.0003993645,0.0006477074,0.01271978,0.00294882,0.2747007,0.2106924,0.01752085,0.3302487,0.0005925439],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.944683,0.01685286,0.006706673,0.003033848,0.0003625551,0.0000659149,0.007607499,0.0006543585,0.0200334],"genre_scores_gemma":[0.9577956,0.006450003,0.006726986,0.0005180095,0.00008780997,0.00006746829,0.01897558,0.0001582816,0.009220178],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00762783,"threshold_uncertainty_score":0.02140403,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02728801777778551,"score_gpt":0.2942585225127531,"score_spread":0.2669705047349676,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}