{"id":"W2022249592","doi":"10.1158/1535-7163.targ-09-b32","title":"Abstract B32: Retrospective correlative study between EGFRvIII, HPV, p16, c-MET and response to EGFR inhibitors in patients with recurrent or metastatic squamous cell carcinoma of the head and neck (R/M SCCHN)","year":2009,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; Princess Margaret Cancer Centre; Ontario Institute for Cancer Research; University of Toronto","funders":"","keywords":"Medicine; Erlotinib; Internal medicine; Oncology; Immunohistochemistry; Cancer; Univariate analysis; Head and neck squamous-cell carcinoma; Head and neck cancer; Epidermal growth factor receptor; Multivariate analysis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004360657,0.0002611109,0.0004459896,0.0004127647,0.0004096897,0.0004396314,0.0002136244,0.0004300353,0.001919573],"category_scores_gemma":[0.0008734622,0.0003200413,0.0003311053,0.0005201746,0.0003106926,0.000361633,0.0002117398,0.0004880088,0.0005244951],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004171259,"about_ca_system_score_gemma":0.0002897291,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001961791,"about_ca_topic_score_gemma":0.001557882,"domain_scores_codex":[0.9997055,0.00005386277,0.00003963661,0.0001105114,0.00004502923,0.00004534679],"domain_scores_gemma":[0.9993755,0.0001455728,0.00020896,0.00006204552,0.00006272465,0.0001451984],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00166221,0.0001100713,0.9949201,0.00001804056,0.00006615615,0.0003187435,0.0000457972,0.0000366531,0.001288158,0.000004867386,0.0001121617,0.001416946],"study_design_scores_gemma":[0.0001429766,0.001709454,0.9951781,0.000005942249,0.0001045348,0.001671828,0.00007980404,0.0001344421,0.00054897,0.00001179494,0.0004073977,0.000004703199],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9992439,0.0001989676,0.0000495551,0.000009508293,0.000003267971,0.00001976293,0.0003026389,0.0000021183,0.0001703797],"genre_scores_gemma":[0.9992731,0.00006099265,0.00004907927,0.0000293879,0.00001019833,0.00002546247,0.0004221247,0.000001345504,0.0001281874],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001961791,"threshold_uncertainty_score":0.006421566,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01821322088672262,"score_gpt":0.3158479395241814,"score_spread":0.2976347186374588,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}