{"id":"W2022249592","doi":"10.1158/1535-7163.targ-09-b32","title":"Abstract B32: Retrospective correlative study between EGFRvIII, HPV, p16, c-MET and response to EGFR inhibitors in patients with recurrent or metastatic squamous cell carcinoma of the head and neck (R/M SCCHN)","year":2009,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; Princess Margaret Cancer Centre; Ontario Institute for Cancer Research; University of Toronto","funders":"","keywords":"Medicine; Erlotinib; Internal medicine; Oncology; Immunohistochemistry; Cancer; Univariate analysis; Head and neck squamous-cell carcinoma; Head and neck cancer; Epidermal growth factor receptor; Multivariate analysis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001379257,0.000240441,0.0004026134,0.0001348221,0.00008550428,0.00001870402,0.00007289833,0.00004719888,0.00001227658],"category_scores_gemma":[0.00002343531,0.0001471436,0.00004322555,0.0004671513,0.00008273278,0.00005428147,0.00003310343,0.0002153544,4.814367e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004104622,"about_ca_system_score_gemma":0.0002536383,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003019631,"about_ca_topic_score_gemma":0.0002325495,"domain_scores_codex":[0.9986079,0.0001268985,0.0003062039,0.0003513372,0.0003805714,0.0002270642],"domain_scores_gemma":[0.9991902,0.00007766714,0.0001592566,0.0002972546,0.0001630917,0.0001125857],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0043474,0.001032128,0.9702943,0.00003002492,0.0002031714,0.00003358903,0.009902725,0.00004095308,0.0006379239,0.000004756544,0.000009897817,0.01346312],"study_design_scores_gemma":[0.00902409,0.008625773,0.9776435,0.000130164,0.0007708121,0.00000140505,0.001081314,0.00000697522,0.002450511,0.00003373519,0.00007043288,0.000161268],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959645,0.001015951,0.00002442821,0.0004911858,0.00006789676,0.00221886,0.0001039643,0.00001043826,0.0001028366],"genre_scores_gemma":[0.9991509,0.00001342412,0.0002166022,0.000433248,0.00001444287,0.00008112625,0.00000825091,0.00002786959,0.00005408765],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01330185,"threshold_uncertainty_score":0.6000344,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01821322088672262,"score_gpt":0.3158479395241814,"score_spread":0.2976347186374588,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}