{"id":"W2022266635","doi":"10.1089/ars.2010.3129","title":"Lysosomal Proteolysis Is the Primary Degradation Pathway for Cytosolic Ferritin and Cytosolic Ferritin Degradation Is Necessary for Iron Exit","year":2010,"lang":"en","type":"article","venue":"Antioxidants and Redox Signaling","topic":"Iron Metabolism and Disorders","field":"Medicine","cited_by":122,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital","funders":"Canadian Institutes of Health Research; Chinese Academy of Sciences","keywords":"Ferritin; Cytosol; Proteases; Biochemistry; Proteolysis; Chemistry; Protein degradation; Cell biology; Biology; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002093349,0.0003355761,0.0005465262,0.0002810586,0.0003593799,0.0005447206,0.0001469131,0.0003376352,0.001421204],"category_scores_gemma":[0.0001830883,0.0001226449,0.000393466,0.0001976404,0.0002587511,0.000279388,0.0002181212,0.0003407568,0.0009087611],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005838041,"about_ca_system_score_gemma":0.0004177476,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000939314,"about_ca_topic_score_gemma":0.0007123275,"domain_scores_codex":[0.9998176,0.00001867646,0.00001649276,0.00004439092,0.00005765121,0.00004523003],"domain_scores_gemma":[0.9998173,0.0000181649,0.00005881822,0.00001689254,0.00005543976,0.00003345913],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002138135,0.00002498643,0.001121755,0.0001941162,0.00001429046,0.0004441066,0.00003758305,0.00005407285,0.9870045,0.0004872046,0.0003498493,0.01005381],"study_design_scores_gemma":[0.00002753609,0.0003340139,0.01992392,0.00004827281,0.00003243613,0.003366335,0.0001366017,0.0008813323,0.9611886,0.0004565705,0.01358778,0.00001662622],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9136686,0.03943121,0.03576995,0.0009451545,0.0002126207,0.0001323779,0.001274978,0.000749708,0.007815437],"genre_scores_gemma":[0.9791445,0.006709228,0.005266969,0.0001303927,0.00005134595,0.00003309243,0.0008568998,0.00004538201,0.007762237],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001421204,"threshold_uncertainty_score":0.004754424,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01654775493756007,"score_gpt":0.2622213854202244,"score_spread":0.2456736304826644,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}