{"id":"W2022285466","doi":"10.1021/bi000280v","title":"Synthesis and Biophysical Properties of Arabinonucleic Acids (ANA):  Circular Dichroic Spectra, Melting Temperatures, and Ribonuclease H Susceptibility of ANA·RNA Hybrid Duplexes","year":2000,"lang":"en","type":"article","venue":"Biochemistry","topic":"DNA and Nucleic Acid Chemistry","field":"Biochemistry, Genetics and Molecular Biology","cited_by":111,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre","funders":"","keywords":"RNA; RNase P; RNase H; DNA; Ribonuclease; Duplex (building); Nucleic acid; Stereochemistry; Chemistry; Oligonucleotide; Nucleic acid structure; Base pair; Biochemistry; Molecular biology; Biology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001541353,0.0003150212,0.0004071063,0.00002377112,0.00009567026,0.0000272108,0.0002372151,0.0002082372,0.00009124853],"category_scores_gemma":[0.0001493848,0.000293519,0.0001446917,0.00008989125,0.0008299978,0.00001015027,0.0001316428,0.0001519386,0.000001339011],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001782173,"about_ca_system_score_gemma":0.00009128819,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005106118,"about_ca_topic_score_gemma":0.000001694531,"domain_scores_codex":[0.9984034,0.0000370853,0.0003964298,0.0006514823,0.00020682,0.0003048389],"domain_scores_gemma":[0.9989638,0.00001699025,0.000146752,0.0006142094,0.00008159458,0.0001766143],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001957772,0.0001636872,0.002689869,0.0007483616,0.0001041144,0.000008970696,0.00003254148,0.000001413903,0.9938834,0.000002687538,0.0002079586,0.001961273],"study_design_scores_gemma":[0.0003957055,0.0000884067,0.001598943,0.000143463,0.00008319346,0.00006154105,0.000130734,0.00007194093,0.9967843,0.00001402504,0.0003094547,0.00031824],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995397,0.003819725,0.000002988253,0.00005645191,0.00001978787,0.0001159587,0.0001045349,0.00002010578,0.0004634297],"genre_scores_gemma":[0.9985784,0.0006938638,0.0002256908,0.00003128664,0.0001825797,0.000009867573,0.00004256774,0.00003564813,0.0002001543],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003181324,"threshold_uncertainty_score":0.9999517,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005363557361457959,"score_gpt":0.1943796134554871,"score_spread":0.1890160560940291,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}