{"id":"W2022285466","doi":"10.1021/bi000280v","title":"Synthesis and Biophysical Properties of Arabinonucleic Acids (ANA):  Circular Dichroic Spectra, Melting Temperatures, and Ribonuclease H Susceptibility of ANA·RNA Hybrid Duplexes","year":2000,"lang":"en","type":"article","venue":"Biochemistry","topic":"DNA and Nucleic Acid Chemistry","field":"Biochemistry, Genetics and Molecular Biology","cited_by":111,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre","funders":"","keywords":"RNA; RNase P; RNase H; DNA; Ribonuclease; Duplex (building); Nucleic acid; Stereochemistry; Chemistry; Oligonucleotide; Nucleic acid structure; Base pair; Biochemistry; Molecular biology; Biology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001964782,0.0003432592,0.0001692349,0.000186041,0.0001472775,0.0002668134,0.0001565763,0.0001923157,0.0005673952],"category_scores_gemma":[0.0002331123,0.0001864596,0.0001228689,0.000167889,0.0001335993,0.0001674173,0.0001085472,0.0002782155,0.0002592475],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001949021,"about_ca_system_score_gemma":0.0001243452,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003233372,"about_ca_topic_score_gemma":0.0005316105,"domain_scores_codex":[0.9998448,0.00003401878,0.00001239869,0.00004254923,0.00004376691,0.0000224267],"domain_scores_gemma":[0.9997976,0.00003903928,0.00004930606,0.00002074102,0.0000454542,0.00004786428],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001161497,0.000004398682,0.00004288936,0.000006955204,0.000001291242,0.000005890781,0.000008639727,0.00002898977,0.9995653,0.00002148287,0.000006737693,0.0002958596],"study_design_scores_gemma":[0.000002969734,0.00005397236,0.0009233525,0.000001322079,0.000005348581,0.00004007123,0.00000942613,0.0003573522,0.9977456,0.00001940194,0.0008361612,0.000005117225],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9854564,0.0007608816,0.01164337,0.00004770348,0.00001746296,0.00005852181,0.0004949799,0.00009816854,0.001422446],"genre_scores_gemma":[0.9845388,0.0005361291,0.01108545,0.0000525514,0.00001196827,0.00009330852,0.001219185,0.00006069576,0.002401866],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005673952,"threshold_uncertainty_score":0.00189817,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005363557361457959,"score_gpt":0.1943796134554871,"score_spread":0.1890160560940291,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}