{"id":"W2022285722","doi":"10.1093/toxsci/kfi318","title":"Basal and Zinc-Induced Metallothionein in Resistance to Cadmium, Cisplatin, Zinc, and tertButyl Hydroperoxide: Studies Using MT Knockout and Antisense-Downregulated MT in Mammalian Cells","year":2005,"lang":"en","type":"article","venue":"Toxicological Sciences","topic":"Trace Elements in Health","field":"Nursing","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"London Health Sciences Centre; Lawson Health Research Institute; Western University; Occupational Cancer Research Centre","funders":"National Institute of Environmental Health Sciences; Canadian Institutes of Health Research","keywords":"Metallothionein; Biology; Molecular biology; Zinc; Cisplatin; Cell culture; Cadmium; HeLa; Cell; Cell biology; Chemistry; Biochemistry; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001911394,0.0002803317,0.0005339192,0.0002742872,0.0004271567,0.00013859,0.0002079259,0.0001687489,0.00002804614],"category_scores_gemma":[0.0004316801,0.0002136948,0.00002100629,0.0007999876,0.0006765329,0.0003933772,0.0002394175,0.0002752061,0.000003905773],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002464683,"about_ca_system_score_gemma":0.00004126089,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002422502,"about_ca_topic_score_gemma":0.008871428,"domain_scores_codex":[0.9969203,0.0004015052,0.0006366264,0.0008823283,0.0003986693,0.000760578],"domain_scores_gemma":[0.9989464,0.0004726761,0.0001469465,0.0001481613,0.00003637265,0.0002494937],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.000254627,0.0002077178,0.04341744,0.00008157297,0.00001152105,0.00007770908,0.00260789,0.0003890132,0.9391387,0.0002357054,0.0001096171,0.01346856],"study_design_scores_gemma":[0.002617336,0.001970608,0.8099927,0.0006282486,0.0000513381,0.00005354552,0.002866282,0.008587953,0.1696052,0.001236225,0.001287259,0.001103285],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9905402,0.001561332,0.000005103294,0.006762268,0.000203007,0.0006886179,0.000005792474,0.00004961263,0.0001840439],"genre_scores_gemma":[0.9879844,0.00009248011,0.01071381,0.001036494,0.00005595154,0.00001535617,3.850473e-7,0.00001227147,0.00008891677],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7695335,"threshold_uncertainty_score":0.8714222,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09598415819399261,"score_gpt":0.3783559380520987,"score_spread":0.2823717798581061,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}