{"id":"W2022285722","doi":"10.1093/toxsci/kfi318","title":"Basal and Zinc-Induced Metallothionein in Resistance to Cadmium, Cisplatin, Zinc, and tertButyl Hydroperoxide: Studies Using MT Knockout and Antisense-Downregulated MT in Mammalian Cells","year":2005,"lang":"en","type":"article","venue":"Toxicological Sciences","topic":"Trace Elements in Health","field":"Nursing","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"London Health Sciences Centre; Lawson Health Research Institute; Western University; Occupational Cancer Research Centre","funders":"National Institute of Environmental Health Sciences; Canadian Institutes of Health Research","keywords":"Metallothionein; Biology; Molecular biology; Zinc; Cisplatin; Cell culture; Cadmium; HeLa; Cell; Cell biology; Chemistry; Biochemistry; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000239293,0.0002998324,0.0004560076,0.0001733159,0.0001428019,0.0003298098,0.0002242051,0.0002946252,0.0009171435],"category_scores_gemma":[0.0001230359,0.0001972144,0.0003080384,0.0002099878,0.0002471186,0.000280903,0.0001715743,0.0005514183,0.000354364],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002586453,"about_ca_system_score_gemma":0.0001636438,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007325571,"about_ca_topic_score_gemma":0.0008403755,"domain_scores_codex":[0.9997562,0.00003708829,0.00005133631,0.00006449372,0.00005889814,0.0000320738],"domain_scores_gemma":[0.9998672,0.00002615099,0.00003403385,0.00002069783,0.00001969349,0.00003212469],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005220804,0.000009722518,0.00005848328,0.00001590786,0.000002624508,0.0000117486,0.000008607728,0.00001529298,0.9996771,0.00001544265,0.00000642629,0.0001264901],"study_design_scores_gemma":[0.00001307577,0.0002208478,0.00234364,0.000001723853,0.00001983937,0.0000985536,0.00002181151,0.0003962114,0.9957935,0.00001201786,0.001075279,0.000003552227],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9940068,0.00147121,0.003054249,0.00007402661,0.00003431282,0.00003453017,0.0006409874,0.00008719307,0.0005965948],"genre_scores_gemma":[0.9924719,0.001087809,0.002609277,0.00004317307,0.00001201663,0.00007611838,0.001260733,0.00003319973,0.00240575],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009171435,"threshold_uncertainty_score":0.003068149,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09598415819399261,"score_gpt":0.3783559380520987,"score_spread":0.2823717798581061,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}