{"id":"W2022292568","doi":"10.1074/jbc.m804847200","title":"The Cyclin-dependent Kinase Activator, Spy1A, Is Targeted for Degradation by the Ubiquitin Ligase NEDD4","year":2008,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University; University of Windsor","funders":"Canadian Institutes of Health Research; Canadian Breast Cancer Research Alliance; University of Windsor","keywords":"Cell cycle; Ubiquitin ligase; Cell biology; Cell growth; Proteasome; Biology; Cyclin B1; Mitosis; Protein degradation; Cyclin; Cyclin B; Cell division control protein 4; Cyclin A; Carcinogenesis; Ubiquitin; Cell cycle checkpoint; Cell Cycle Protein; Cell; Cyclin-dependent kinase 1; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001602132,0.0002900563,0.0002814013,0.0002527823,0.0002642681,0.0004390449,0.0002174882,0.0002497289,0.0009771009],"category_scores_gemma":[0.0002189797,0.0002128263,0.0002396114,0.0001685502,0.0003274198,0.0002793974,0.0002818451,0.0003963747,0.0005596018],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005353097,"about_ca_system_score_gemma":0.0002993271,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004954014,"about_ca_topic_score_gemma":0.0005863148,"domain_scores_codex":[0.999891,0.00001442401,0.000009504656,0.00003586637,0.00002865743,0.00002046934],"domain_scores_gemma":[0.9998683,0.00001451253,0.00005759451,0.0000138782,0.00001838405,0.00002741905],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000157285,0.00001089228,0.001011329,0.00005410195,0.000009967288,0.0001626169,0.0000122402,0.0001471494,0.9935569,0.0004045676,0.0001357345,0.004337239],"study_design_scores_gemma":[0.00001723139,0.00009840653,0.007126333,0.000005148306,0.00001187092,0.001375066,0.0000257338,0.001949247,0.9817408,0.0002386776,0.007406265,0.000005243593],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.986131,0.005780227,0.006369505,0.0001487195,0.00004020789,0.00001758764,0.0003158003,0.00008545782,0.001111531],"genre_scores_gemma":[0.99318,0.001559105,0.002387964,0.00002925141,0.00001099242,0.00001070155,0.000550147,0.00002340129,0.00224836],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009771009,"threshold_uncertainty_score":0.003883958,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.027417972680186,"score_gpt":0.2603617656053295,"score_spread":0.2329437929251435,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}