{"id":"W2022297142","doi":"10.1002/adfm.200800860","title":"Self‐Assembling Peptide as a Potential Carrier for Hydrophobic Anticancer Drug Ellipticine: Complexation, Release and In Vitro Delivery","year":2008,"lang":"en","type":"article","venue":"Advanced Functional Materials","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":95,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; University of Toronto; University of Waterloo","funders":"","keywords":"Peptide; Protonation; Liposome; In vitro; Chemistry; Vesicle; Drug delivery; Biophysics; Membrane; Drug carrier; Hydrophobic effect; In vivo; Phosphatidylcholine; Combinatorial chemistry; Stereochemistry; Biochemistry; Organic chemistry; Biology; Phospholipid","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002215931,0.0001984207,0.0001693098,0.00008199459,0.0001081035,0.0001520598,0.0001318953,0.0002057634,0.0004084243],"category_scores_gemma":[0.0001611453,0.00008536156,0.00008214203,0.00006969502,0.0001227824,0.0001638948,0.0001175345,0.0001971557,0.0001570395],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001830288,"about_ca_system_score_gemma":0.00009407097,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003081065,"about_ca_topic_score_gemma":0.0003301921,"domain_scores_codex":[0.999896,0.00003406282,0.000007844287,0.00002083858,0.00002714412,0.00001400208],"domain_scores_gemma":[0.9999171,0.0000258379,0.00002508839,0.000007747356,0.0000130214,0.00001127003],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000169253,0.000007882382,0.00002232235,0.00001324623,0.000001087162,0.00001336003,0.000006510303,0.00006223569,0.9994022,0.00002157851,0.000004685352,0.0004280075],"study_design_scores_gemma":[0.000003722451,0.0001024915,0.0001828072,7.923243e-7,0.000002188362,0.00002625951,0.000002253328,0.0006169758,0.9987316,0.000004571219,0.0003253009,0.000001163121],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9933702,0.0009860542,0.004953319,0.00003011362,0.00001036318,0.00003635577,0.00005340727,0.00003822703,0.0005219246],"genre_scores_gemma":[0.9931052,0.0003866215,0.004977198,0.00001295207,0.000005328562,0.00002885952,0.00008200829,0.00001321069,0.001388715],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0004084243,"threshold_uncertainty_score":0.001366258,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009933950192239355,"score_gpt":0.2341191343897913,"score_spread":0.2241851841975519,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}