{"id":"W2022297142","doi":"10.1002/adfm.200800860","title":"Self‐Assembling Peptide as a Potential Carrier for Hydrophobic Anticancer Drug Ellipticine: Complexation, Release and In Vitro Delivery","year":2008,"lang":"en","type":"article","venue":"Advanced Functional Materials","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":95,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; University of Toronto; University of Waterloo","funders":"","keywords":"Peptide; Protonation; Liposome; In vitro; Chemistry; Vesicle; Drug delivery; Biophysics; Membrane; Drug carrier; Hydrophobic effect; In vivo; Phosphatidylcholine; Combinatorial chemistry; Stereochemistry; Biochemistry; Organic chemistry; Biology; Phospholipid","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009989039,0.0001590546,0.0001925673,0.00006296353,0.0001298951,0.00002010233,0.00006636253,0.00007336965,0.0000499057],"category_scores_gemma":[0.00005033597,0.0001595772,0.0000493455,0.00005536179,0.00005627031,0.00002079991,0.00004531075,0.0000406693,0.00001147346],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002418523,"about_ca_system_score_gemma":0.00008621137,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005415806,"about_ca_topic_score_gemma":0.000010663,"domain_scores_codex":[0.9989876,0.00003767719,0.0002775117,0.0003677282,0.0001106718,0.0002188636],"domain_scores_gemma":[0.9995159,0.00002369746,0.00009222118,0.0001485073,0.000157816,0.00006189146],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001953781,0.00003944218,0.0001767486,0.00003055896,0.00003290701,0.000008348417,0.00003142716,0.001061156,0.99605,0.00001395995,0.0004917592,0.0001099244],"study_design_scores_gemma":[0.001294489,0.0001566049,0.003159472,0.00001866888,0.0000226529,0.00007393259,0.00005473732,0.0002678154,0.9916839,0.0002015685,0.002853093,0.0002130632],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977027,0.0004972005,0.0008575873,0.00008884398,0.0004150558,0.000284287,0.00009850967,0.00001577546,0.00004003692],"genre_scores_gemma":[0.9957087,0.0007999704,0.001554169,0.0005267445,0.0003789041,0.00009180913,0.0003980581,0.00002266779,0.0005189627],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004366085,"threshold_uncertainty_score":0.6507368,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009933950192239355,"score_gpt":0.2341191343897913,"score_spread":0.2241851841975519,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}