{"id":"W2022309076","doi":"10.1007/s10549-012-2188-0","title":"Cross-platform pathway-based analysis identifies markers of response to the PARP inhibitor olaparib","year":2012,"lang":"en","type":"article","venue":"Breast Cancer Research and Treatment","topic":"PARP inhibition in cancer therapy","field":"Medicine","cited_by":74,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Institutes of Health Research; Office of Science; Breast Cancer Research Foundation; Pfizer; National Cancer Institute; National Institutes of Health; Cancer Research UK; Belgian American Educational Foundation; Stand Up To Cancer; U.S. Department of Energy","keywords":"Olaparib; Synthetic lethality; Biology; DNA repair; PARP inhibitor; Homologous recombination; Cancer research; Gene; Genetics; DNA damage; Molecular biology; Poly ADP ribose polymerase; DNA; Polymerase","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002792336,0.0002605583,0.000326149,0.001049862,0.0001380186,0.0003626269,0.0001607134,0.0003307926,0.00091714],"category_scores_gemma":[0.0006656271,0.0001188346,0.0002445278,0.0005493255,0.0001309776,0.0001243906,0.000244828,0.0002081481,0.0002074526],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002877498,"about_ca_system_score_gemma":0.0001760327,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001358794,"about_ca_topic_score_gemma":0.001529911,"domain_scores_codex":[0.9998329,0.0000236603,0.00001443432,0.00006520073,0.00003220838,0.00003168757],"domain_scores_gemma":[0.9996811,0.0001539371,0.00007189933,0.00001974601,0.00003944382,0.00003386119],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001854915,0.0003150809,0.4588683,0.0001267907,0.0001755866,0.0002641118,0.0001448748,0.01490985,0.475712,0.0001982993,0.0003106311,0.04711967],"study_design_scores_gemma":[0.00003646509,0.0007178252,0.7347405,0.00001141226,0.0001055771,0.0005758368,0.0001878275,0.1614503,0.1008541,0.0004555324,0.0008394908,0.00002511858],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9955409,0.000117377,0.003481144,0.00001205882,0.000001559864,0.00001749732,0.0004563619,0.0001212576,0.0002518626],"genre_scores_gemma":[0.9925334,0.00006628914,0.005431315,0.00001733747,0.000001471358,0.00003797126,0.001569499,0.00001357146,0.0003291585],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001358794,"threshold_uncertainty_score":0.003068149,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07377723545298644,"score_gpt":0.4121557303094759,"score_spread":0.3383784948564895,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}