{"id":"W2022326153","doi":"10.1177/0091270003261496","title":"Effect of St. John's Wort on the Pharmacokinetics of Theophylline in Healthy Volunteers","year":2003,"lang":"en","type":"article","venue":"The Journal of Clinical Pharmacology","topic":"Natural Compound Pharmacology Studies","field":"Agricultural and Biological Sciences","cited_by":62,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Theophylline; Pharmacokinetics; Urine; Crossover study; Hypericum perforatum; Pharmacology; Medicine; Oral administration; Plasma concentration; Internal medicine","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01042178,0.0001927528,0.0008464079,0.00003704313,0.0001009945,0.000003243445,0.0007609174,0.0001260339,0.0006949846],"category_scores_gemma":[0.001033647,0.00005125281,0.0003331815,0.0004709144,0.0006669237,0.00004358196,0.00008472761,0.001288285,0.000005703773],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002364325,"about_ca_system_score_gemma":0.00004155663,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001968639,"about_ca_topic_score_gemma":0.00002447706,"domain_scores_codex":[0.9920951,0.005580091,0.001543677,0.0001432768,0.0003318988,0.0003059909],"domain_scores_gemma":[0.9757343,0.02274937,0.001123935,0.00006775051,0.0002271183,0.00009753381],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0746076,0.003363373,0.08775663,0.0001694553,0.002132793,0.0001088405,0.000514397,0.00247951,0.6428865,0.001142533,0.1185306,0.06630778],"study_design_scores_gemma":[0.02777021,0.1064642,0.2622467,0.0002868678,0.002944624,0.0002651394,0.0008881751,0.0007809635,0.3761634,0.004974898,0.2161568,0.001058038],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9848695,0.001401073,8.96456e-7,0.01066866,0.002154006,0.000393389,0.00001307934,0.000004805544,0.0004946373],"genre_scores_gemma":[0.9934322,0.002454991,0.00001456846,0.00346862,0.0005873428,0.000004127152,7.085443e-7,0.000001990833,0.00003547362],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2667231,"threshold_uncertainty_score":0.7609594,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05293921569807965,"score_gpt":0.4047689388473475,"score_spread":0.3518297231492679,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}