{"id":"W2022371765","doi":"10.2741/3003","title":"The RSK factors of activating the Ras/MAPK signaling cascade","year":2008,"lang":"en","type":"review","venue":"Frontiers in bioscience","topic":"Melanoma and MAPK Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":222,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute for Research in Immunology and Cancer","funders":"National Cancer Institute; Terry Fox Foundation","keywords":"MAPK/ERK pathway; Gene isoform; Ribosomal s6 kinase; Kinase; Cell biology; Biology; Signal transduction; Effector; Protein kinase A; MAPK cascade; Gene; Biochemistry; PI3K/AKT/mTOR pathway; P70-S6 Kinase 1","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002537704,0.001233694,0.0007685035,0.001675476,0.0002710019,0.0008220354,0.0007562151,0.0007444847,0.002826088],"category_scores_gemma":[0.0002296024,0.0002662399,0.0003053582,0.001200952,0.0005380074,0.001125165,0.0005613862,0.001359059,0.00453927],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006000315,"about_ca_system_score_gemma":0.0005792069,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005997767,"about_ca_topic_score_gemma":0.0009038829,"domain_scores_codex":[0.9998676,0.00001731907,0.00001353992,0.0000329488,0.00005450694,0.00001409791],"domain_scores_gemma":[0.9999298,0.00001679212,0.00001582227,0.000003822276,0.00002098803,0.00001276253],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00008633872,0.00005622053,0.0001780651,0.004659035,0.00004247477,0.0003544106,0.00005227722,0.0004150702,0.01020978,0.00610457,0.0148068,0.9630349],"study_design_scores_gemma":[0.00002079252,0.00005283285,0.0007872675,0.0004569205,0.00003142122,0.001856435,0.00003543344,0.0001136523,0.005056118,0.002296721,0.9892755,0.00001695025],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0005976688,0.9926138,0.001004555,0.0002512195,0.0002360153,0.00001401609,0.00003323574,0.0000476189,0.005201943],"genre_scores_gemma":[0.003494122,0.9917858,0.0008828505,0.0001570141,0.0002005991,0.00002384707,0.00007622036,0.000004730001,0.003374735],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002826088,"threshold_uncertainty_score":0.00945425,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0306186198857923,"score_gpt":0.2817528382859497,"score_spread":0.2511342184001574,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}