{"id":"W2022388285","doi":"10.1016/j.bmcl.2008.03.005","title":"Synthesis of 17β-estradiol-platinum(II) hybrid molecules showing cytotoxic activity on breast cancer cell lines","year":2008,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Metal complexes synthesis and properties","field":"Medicine","cited_by":55,"is_retracted":false,"has_abstract":false,"ca_institutions":"Memorial University of Newfoundland; College of the North Atlantic; Université du Québec à Trois-Rivières","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Chemistry; MCF-7; Stereochemistry; PEG ratio; Estrone; Chemical synthesis; Ligand (biochemistry); Platinum; Pyridine; Molecule; Combinatorial chemistry; Cancer; Breast cancer; In vitro; Biochemistry; Organic chemistry; Human breast; Internal medicine; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0002050235,0.0004148876,0.0007925176,0.00005033304,0.0002026409,0.000008259257,0.0002642327,0.0001123816,0.001169702],"category_scores_gemma":[0.0001856193,0.0003216986,0.0002366499,0.0001642673,0.000358695,0.00008296739,0.00006712156,0.0003446912,0.00001501286],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001949899,"about_ca_system_score_gemma":0.0001906501,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003087732,"about_ca_topic_score_gemma":0.000002418557,"domain_scores_codex":[0.9978419,0.00006017605,0.0004626673,0.0005144558,0.0006903326,0.0004304592],"domain_scores_gemma":[0.9986832,0.0001987439,0.0002520128,0.0005344881,0.00008335592,0.0002482093],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004449993,0.0002336882,0.001291028,0.0006086426,0.0001641657,0.0001533343,0.0001364643,0.000004231404,0.9936594,5.852002e-7,0.00155251,0.001750904],"study_design_scores_gemma":[0.000569716,0.00009206756,0.01045293,0.0007075624,0.0002564933,0.0009934556,0.00009133026,0.00008646466,0.9861798,0.00000104971,0.0002700271,0.0002990578],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.992497,0.0008248082,0.00003720301,0.004548802,0.0001192567,0.0001977225,0.00008995237,0.00007633362,0.001608976],"genre_scores_gemma":[0.9974169,0.0003296145,0.0001843249,0.0009726409,0.0007462866,0.00002995897,0.00001208935,0.00006142297,0.0002467504],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009161904,"threshold_uncertainty_score":0.9999235,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03236335677840349,"score_gpt":0.2353923644285082,"score_spread":0.2030290076501047,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}