{"id":"W2022398116","doi":"10.1074/jbc.m115.638395","title":"Cysteine Cathepsins Activate ELR Chemokines and Inactivate Non-ELR Chemokines","year":2015,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Protease and Inhibitor Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":86,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Centre for Blood Research, University of British Columbia; Michael Smith Health Research BC","keywords":"Cathepsin; Proteases; Chemistry; Biochemistry; Chemokine; Cathepsin B; Biology; Cell biology; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003795488,0.0002649346,0.000377486,0.0000261802,0.000055831,0.00003285006,0.000278681,0.0003980475,0.00002057526],"category_scores_gemma":[0.0004028,0.0001835548,0.0001539522,0.00009230605,0.0001347791,0.00001578575,0.0002066583,0.0002821141,0.000002873433],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000368257,"about_ca_system_score_gemma":0.0001147092,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004527765,"about_ca_topic_score_gemma":2.786731e-7,"domain_scores_codex":[0.998767,0.00003370881,0.0004139913,0.0002993083,0.0001962896,0.0002897115],"domain_scores_gemma":[0.9987928,0.0000165304,0.0003889179,0.0002370531,0.0002334901,0.0003311897],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003985646,0.0001178984,0.0007257602,0.00003042052,0.00006186184,0.00004398803,0.00001919724,0.000002757257,0.9963044,0.000003734873,0.001378475,0.0009129335],"study_design_scores_gemma":[0.001239892,0.0007520891,0.0002714184,0.00004837599,0.00002285704,0.0006595394,0.0001107836,0.00001015739,0.9838519,0.0003440771,0.01244423,0.0002447366],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967771,0.001023452,0.0002172517,0.0003270679,0.0001729723,0.00008615892,0.00001288098,0.00001074719,0.001372356],"genre_scores_gemma":[0.9971521,0.0002967318,0.0005526107,0.000210046,0.001309563,0.000006120036,0.00002756032,0.00001876016,0.000426462],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01245256,"threshold_uncertainty_score":0.7485149,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02305376737806886,"score_gpt":0.2496734059945251,"score_spread":0.2266196386164563,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}