{"id":"W2022398116","doi":"10.1074/jbc.m115.638395","title":"Cysteine Cathepsins Activate ELR Chemokines and Inactivate Non-ELR Chemokines","year":2015,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Protease and Inhibitor Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":86,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Centre for Blood Research, University of British Columbia; Michael Smith Health Research BC","keywords":"Cathepsin; Proteases; Chemistry; Biochemistry; Chemokine; Cathepsin B; Biology; Cell biology; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003729865,0.000661519,0.0003494546,0.0002366077,0.0001141243,0.0003589162,0.0001802891,0.0003975908,0.001487851],"category_scores_gemma":[0.0003558887,0.0001373176,0.0005377398,0.000192489,0.000273777,0.0002722436,0.0002028701,0.000408412,0.0003863931],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000262662,"about_ca_system_score_gemma":0.0002180137,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005067386,"about_ca_topic_score_gemma":0.0007174973,"domain_scores_codex":[0.9994913,0.00009456802,0.00005104779,0.00006311201,0.0001237651,0.0001761991],"domain_scores_gemma":[0.9997156,0.00006245698,0.00009890894,0.00003739057,0.00004796596,0.00003771413],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001016401,0.0000177004,0.0003006325,0.00006463088,0.000008401851,0.00008268655,0.00001772938,0.00002161787,0.9985353,0.00003175473,0.00002595276,0.0007918748],"study_design_scores_gemma":[0.00001895663,0.0002776459,0.01120747,0.00001322291,0.0000148708,0.0005542046,0.00003750101,0.000336515,0.985514,0.0000327764,0.001986946,0.00000581398],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.991808,0.004489299,0.002059412,0.00008063532,0.00002722064,0.00003907362,0.0003292383,0.00006064916,0.001106486],"genre_scores_gemma":[0.9925324,0.001765977,0.002690654,0.0001150993,0.00002317053,0.00003655656,0.0006227879,0.00001965543,0.002193797],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001487851,"threshold_uncertainty_score":0.004977345,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02305376737806886,"score_gpt":0.2496734059945251,"score_spread":0.2266196386164563,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}