{"id":"W2022399016","doi":"10.1073/pnas.0610543104","title":"Interaction of the Wiskott–Aldrich syndrome protein with sorting nexin 9 is required for CD28 endocytosis and cosignaling in T cells","year":2007,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Cell Adhesion Molecules Research","field":"Medicine","cited_by":103,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto General Hospital; Lunenfeld-Tanenbaum Research Institute; University of Toronto; Sunnybrook Health Science Centre; Mount Sinai Hospital","funders":"","keywords":"Biology; Cell biology; Wiskott–Aldrich syndrome protein; Sorting nexin; CD28; Endocytic cycle; Endocytosis; Internalization; Dynamin; T cell; Actin cytoskeleton; Cytoskeleton; Immunology; Receptor; Immune system; Cell; Endosome; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002277079,0.00007649011,0.0001773703,0.0002564354,0.0001088523,0.00001294814,0.0003009753,0.00005793315,0.000006510105],"category_scores_gemma":[0.000664019,0.00004254178,0.00005307561,0.0009453733,0.0005370803,0.00022086,0.0001090883,0.0001942675,1.551259e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006026678,"about_ca_system_score_gemma":0.00005713812,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001852144,"about_ca_topic_score_gemma":4.360813e-7,"domain_scores_codex":[0.998055,0.000007219912,0.0004089152,0.0002090449,0.001144703,0.0001751621],"domain_scores_gemma":[0.9988936,0.0002264576,0.0004869569,0.00001141257,0.000346973,0.00003463602],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001671732,0.00004884326,0.01589552,0.0002356661,0.00001104664,2.996924e-8,0.0002871419,0.00001707353,0.9820477,0.0008303749,0.00003182529,0.0004275895],"study_design_scores_gemma":[0.0004565761,0.000185943,0.04344654,0.0006302145,0.00001308275,0.00002620106,0.0005882024,0.001267552,0.9512106,0.002103515,0.00002811443,0.00004341254],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957434,0.00005611763,0.000009825609,0.002648965,0.000006191288,0.0007931192,0.000003178176,0.000003521066,0.0007356882],"genre_scores_gemma":[0.9971413,0.000007803005,0.002534011,0.0001215345,0.00001657667,0.00001949652,6.002821e-8,0.000005242382,0.0001539685],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03083707,"threshold_uncertainty_score":0.1978895,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05873596367845051,"score_gpt":0.3518113203929559,"score_spread":0.2930753567145054,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}